Platelet Distribution Width (PDW) in Thrombocytopenia.
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Date
2015-05
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Abstract
Background: Platelet volume parameters are significant
especially in diagnosis of causes of thrombocytopenia. The
platelet parameters are widely available as part of full blood
count with no extra cost. Thrombocytopenia is of varying
etiology based on which it is broadly divided into three
major categories (1) as increased destruction, (2) decreased
production and (3) splenic sequestration/abnormal pooling.
The present study was undertaken to understand relation
between cause of thrombocytopenia and Platelet Distribution
Width as well as other platelet parameters. Materials and
Methods: 500 cases of Thrombocytopenia (TCP) and 300
control cases having normal platelet count were selected.
TCP was defined as platelet count <1.5lakh/ìl. Analysis was
done by Sysmex KX 21 cell counter and every case was
reassessed by Peripheral Smear (P.S.) examination and if
necessary also by manual method. Only those cases that
had sufficient clinico-hematological work -up and the causes
of low platelet count had been reliably established were
included in the study. Results: The study was conducted
on 500 cases they were broadly categorized into three
groups Group A with accelerated platelet Destruction Group
B with Impaired production and Group C with abnormal
pooling. Out of 500 cases 272 (54%) were male and
228(46%) were female. A slight male preponderance was
seen in overall picture as well as in almost all age groups.
The overall male to female ratio being 1.19 : 1. Mean platelet
volume [MPV] was statistically significant with ‘p’ values
Description
Keywords
thrombocytopenia [TCP], mean platelet volume [MPV], platelet distribution width [PDW]
Citation
Reddy R. Shridhar, Khan Mohd Inayatulla, Phansalkar Manjiri Dilip. Platelet Distribution Width (PDW) in Thrombocytopenia. Indian Medical Gazette. 2015 May; 149(5):169-173.