Antibacterial activity of the antiinflammatory agent diclofenac sodium.

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dc.contributor.authorAnnadurai, Sen_US
dc.contributor.authorBasu, Sen_US
dc.contributor.authorRay, Sen_US
dc.contributor.authorDastidar, S Gen_US
dc.contributor.authorChakrabarty, A Nen_US
dc.date.accessioned2009-05-28T15:37:55Z
dc.date.available2009-05-28T15:37:55Z
dc.date.issued1998-01-16en_US
dc.description.abstractAntimicrobial property of ten antiinflammatory drugs was tested with eleven sensitive bacteria belonging to both Gram positive and Gram negative types. Since most of the bacteria were moderate to highly sensitive to diclofenac (Dc), this compound was tested in vitro against 397 bacteria, most of which were inhibited by Dc at 50-100 micrograms/ml level. When tested in vivo, Dc at 1.5 and 3.0 micrograms/g body weight of a Swiss strain of white mice, could significantly protect the animals challenged with 50 MLD of Salmonella typhimurium NCTC 74. According to chi 2 test the in vivo data were highly significant (P < 0.001).en_US
dc.description.affiliationDepartment of Pharmaceutical Technology, Jadavpur University, Calcutta, India.en_US
dc.identifier.citationAnnadurai S, Basu S, Ray S, Dastidar SG, Chakrabarty AN. Antibacterial activity of the antiinflammatory agent diclofenac sodium. Indian Journal of Experimental Biology. 1998 Jan; 36(1): 86-90en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62218
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Bacterial Agents --pharmacologyen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --pharmacologyen_US
dc.subject.meshDiclofenac --pharmacologyen_US
dc.subject.meshGram-Negative Bacteria --drug effectsen_US
dc.subject.meshGram-Positive Bacteria --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Strainsen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshSalmonella Infections, Animal --drug therapyen_US
dc.titleAntibacterial activity of the antiinflammatory agent diclofenac sodium.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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