Effect of ramipril on glycosylated hemoglobin and liver function test in patients of diabetic nephropathy.

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dc.contributor.authorGupta, Dharmender
dc.contributor.authorAnsari, N A
dc.contributor.authorSayedda, Kauser
dc.date.accessioned2015-11-04T09:45:43Z
dc.date.available2015-11-04T09:45:43Z
dc.date.issued2015-03
dc.description.abstractBackground: Diabetic nephropathy (DN) is a chronic complication of diabetes mellitus with a growing incidence. Therefore, it is essential to have a better understanding of it, especially in relation to prevention and aggressive management to avoid progression to end-stage renal disease. Methods: This prospective randomized study represented the effects of ramipril on glycosylated hemoglobin (HbA1c), liver function tests (LFT), mean arterial blood pressure, and serum potassium level in patients diagnosed with DN, with concomitant mild to moderate hypertension. 135 diagnosed patients with DN treated with ramipril 5 mg daily for 3 months were involved in this study. Blood samples were taken from all patients and analyzed for HbA1c, LFT including alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum alkaline phosphatase (ALP), and bilirubin with serum potassium level. After 3 months of treatment with ramipril (5 mg daily), blood samples were collected and analyzed again to determine the same parameters. Results: Ramipril produced a signifi cant reduction in (HbA1c) of hypertensive patients (p<0.05), whereas, serum levels of ALT, AST, ALP, and bilirubin were signifi cantly elevated. The results indicated that ramipril may cause liver injury. Meanwhile, the mean arterial pressure was decreased signifi cantly by ramipril (p<0.05). Conclusion: The present study concluded that: ramipril signifi cantly reduced the percentage of HbA1c but may cause liver injury, monitoring of liver enzymes is advisable for patients on ramipril.en_US
dc.identifier.citationGupta Dharmender, Ansari N A, Sayedda Kauser. Effect of ramipril on glycosylated hemoglobin and liver function test in patients of diabetic nephropathy. International Journal of Basic & Clinical Pharmacology. 2015 Mar-Apr; 4(2): 312-316.en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/165062
dc.language.isoenen_US
dc.source.urihttps://www.ijbcp.com/?mno=175860en_US
dc.subjectRamiprilen_US
dc.subjectGlycosylated hemoglobinen_US
dc.subjectLiver function testen_US
dc.subjectDiabetic nephropathyen_US
dc.titleEffect of ramipril on glycosylated hemoglobin and liver function test in patients of diabetic nephropathy.en_US
dc.typeArticleen_US
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