Clonidine, dexmedetomidine: alpha-2 adrenergic receptor agonists in neuroscience

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dc.contributor.authorEldufani, Jabril B.en_US
dc.contributor.authorElahmer, Nyruz R.en_US
dc.contributor.authorNekoui, Alirezaen_US
dc.contributor.authorBlaise, Gilbert A.en_US
dc.date.accessioned2020-04-23T07:53:01Z
dc.date.available2020-04-23T07:53:01Z
dc.date.issued2018-12
dc.description.abstractThe alpha-2 adrenergic receptor (?-2 AR) agonists have a long history of use in treating different clinical conditions, such as hypertension, psychiatric entities (e.g., attention-deficit hyperactivity disorder), chronic pain, panic disorders, and, lately, for treating opioid withdrawal syndrome. In recent years, ?-2 AR medications have been administered as adjuncts for managing inflammatory conditions, depression, chronic pain, sleep and cognitive disorders. This review will provide some clinical applications in neuroscience for this class of drugs. Understanding the pharmacological mechanisms is essential to obtaining neurochemical data that demonstrate that ?-2 AR agonists have potential clinical significance in neuroscience.en_US
dc.identifier.affiliationsDepartment of Medicine, University of Montreal, Montreal, Quebec, Canadaen_US
dc.identifier.affiliationsDepartment of Pharmacology and Physiology, University of Montreal, Montreal, Quebec, Canadaen_US
dc.identifier.affiliationsDepartment of Anesthesiology and Pain Management, Management, University Hospital of Montreal (CHUM), Montreal, Quebec, Canadaen_US
dc.identifier.citationEldufani Jabril B., Elahmer Nyruz R., Nekoui Alireza, Blaise Gilbert A.. Clonidine, dexmedetomidine: alpha-2 adrenergic receptor agonists in neuroscience. International Journal of Basic & Clinical Pharmacology. 2018 Dec; 7(12): 2476-2482en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199961
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber12en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20184870en_US
dc.subject?-2 AR agonistsen_US
dc.subjectCognitiveen_US
dc.subjectDepressionen_US
dc.subjectImmune systemen_US
dc.subjectPainen_US
dc.subjectSleepen_US
dc.titleClonidine, dexmedetomidine: alpha-2 adrenergic receptor agonists in neuroscienceen_US
dc.typeJournal Articleen_US
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