IDPH-8261--a new nonsteroidal antiinflammatory agent.

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dc.contributor.authorRao, C Sen_US
dc.contributor.authorSingh, P Pen_US
dc.contributor.authorJunnarkar, A Yen_US
dc.contributor.authorMuralidhar, Nen_US
dc.contributor.authorTrivedi, B Sen_US
dc.contributor.authorRao, B Een_US
dc.date.accessioned2009-05-28T12:02:21Z
dc.date.available2009-05-28T12:02:21Z
dc.date.issued1995-01-01en_US
dc.description.abstractIDPH-8261, methyl alpha-methyl-4-(3-thienyl)benzeneacetate, exhibited marked anti-inflammatory activity in acute, subacute and chronic models of inflammation. In rats, IDPH-8261 exhibited a dose related inhibition of carrageenin-induced rat paw edema and the inhibition was greater than ibuprofen, phenylbutazone, but was three times less than indomethacin. It exhibited anti-inflammatory activity in normal and adrenalectomized rats. It also exhibited the activity against various phlogistic agents. IDPH-8261 exhibited AI activity in subacute granuloma tests. In adjuvant-induced established polyarthritis. IDPH-8261 exhibited anti-arthritic effect at a very low dose (ED50 = 4 mg/kg, p.o.). Ulcerogenic liability was the lowest (UD50 = 180 mg/kg, p.o.), when compared to reference standard drugs. Low toxicity and high efficacy may make this compound a potentially useful therapeutic agent.en_US
dc.description.affiliationDepartment of Pharmacology, IDPL Research Center, Hyderabad, India.en_US
dc.identifier.citationRao CS, Singh PP, Junnarkar AY, Muralidhar N, Trivedi BS, Rao BE. IDPH-8261--a new nonsteroidal antiinflammatory agent. Indian Journal of Experimental Biology. 1995 Jan; 33(1): 28-33en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/57540
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --chemical synthesisen_US
dc.subject.meshCarrageenan --pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEdema --chemically induceden_US
dc.subject.meshPhenylacetates --chemical synthesisen_US
dc.subject.meshRatsen_US
dc.subject.meshUlcer --drug therapyen_US
dc.titleIDPH-8261--a new nonsteroidal antiinflammatory agent.en_US
dc.typeJournal Articleen_US
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