The impact of anti-tumor necrosis factor alpha drugs on lipid profile of patients with rheumatoid arthritis or seronegative spondyloarthropathy

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dc.contributor.authorMohammadi-Kebar, Y.en_US
dc.contributor.authorZandian, H.en_US
dc.contributor.authorKhazdooz, Z.en_US
dc.date.accessioned2024-09-24T06:13:57Z
dc.date.available2024-09-24T06:13:57Z
dc.date.issued2024-02
dc.description.abstractBackground: Inflammatory arthritis is associated with abnormal levels of lipoprotein. The cause is considered to be inflammation. Recently, the use of biologic drugs in the treatment of inflammatory arthritis, especially rheumatoid arthritis (RA) and seronegative spondyloarthropathy, has increased. There are different results of the effect of these drugs on fat profile. Evaluate the impact of anti-tumor necrosis factor (TNF) alpha drugs on lipid profile of patients with RA or seronegative spondyloarthritis. Methods: In this cross-sectional descriptive study, 50 patients with rheumatoid arthritis or seronegative spondyloarthritis, who were candidates for TNF alpha treatment, were included in the study. After obtaining written consent, a checklist was completed for all patients including demographic information such as age, sex, height, weight, place of residence, level of education, type of disease, and lipid profile test results including total cholesterol, triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) were recorded. Then the patients were treated and evaluated for fat profile after 3, 6, 9 months after receiving the relevant treatment regimen. The test results were recorded in checklists. After completing the study, the data were entered into the statistical package for the social sciences (SPSS) 24 software and analyzed. Results: The mean age of patients was 46.38±14.33 years. 54% of patients were female. 54% of patients had rheumatoid arthritis. 62% of patients were treated with Sinora. The results of this study showed that serum triglyceride levels increased during the study period and this increase was statistically significant but the trend of changes in serum cholesterol, HDL and LDL levels was not statistically significant. However, serum LDL levels measured in the ninth month increased significantly compared to the initial measurement. Conclusions: Results showed that there was a significant relationship between lipid profile changes and anti-TNF alpha consumption. Although decreased inflammation appears but other mechanisms may be involved in dyslipidemia.en_US
dc.identifier.affiliationsDepartment of Internal Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iranen_US
dc.identifier.affiliationsDepartment of Community Medicine, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iranen_US
dc.identifier.affiliationsSchool of Medicine, Ardabil University of Medical Sciences, Ardabil, Iranen_US
dc.identifier.citationMohammadi-Kebar Y., Zandian H., Khazdooz Z.. The impact of anti-tumor necrosis factor alpha drugs on lipid profile of patients with rheumatoid arthritis or seronegative spondyloarthropathy. International Journal of Basic & Clinical Pharmacology. 2024 Jan; 13(1): 47-50en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226758
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume13en_US
dc.source.urihttps://doi.org/10.18203/2319-2003.ijbcp20233890en_US
dc.subjectLipid profileen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectSeronegative spondyloarthritisen_US
dc.titleThe impact of anti-tumor necrosis factor alpha drugs on lipid profile of patients with rheumatoid arthritis or seronegative spondyloarthropathyen_US
dc.typeJournal Articleen_US
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