Plasma pharmacokinetics of a generic amoxycillin and the innovator brand: a comparison.

No Thumbnail Available
Date
1998-03-13
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
OBJECTIVE: To compare the bioavailability and plasma pharmacokinetics of a generic brand of amoxycillin (State Pharmaceutical Manufacturing Coporation) selected from the lower price range, with that of the innovation brand (Amoxil, Beecham). DESIGN: Sixteen healthy adult volunteers were allotted to two groups and each group was given a test dose of amoxycillin from each brand. Blood samples were collected at 0, 2, 3 and 4 hours thereafter plasma levels were assayed using high performance liquid chromatography. RESULTS: Analysis of results show that the generic product had similar bioavailability and pharmacokinetics when compared with the innovator product. CONCLUSION: The quality assured generic amoxycillin tested had similar bioavailability as a more costly branded version.
Description
The Ceylon Medical Journal.
Keywords
Citation
Goonetilleke AK, Munasingha JM, Guruge DS, Samaraweera DS, Weerasena OV. Plasma pharmacokinetics of a generic amoxycillin and the innovator brand: a comparison. The Ceylon Medical Journal. 1998 Mar; 43(1): 16-8
URI
https://imsear.searo.who.int/handle/123456789/48191
Collections
Ceylon Medical Journal