Comparison of efficacy and safety of ketoprofen patch versus diclofenac patch as post-operative analgesic in hysterectomy patients

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dc.contributor.authorRani, Seemaen_US
dc.contributor.authorSavant, Meenakshien_US
dc.contributor.authorMahendru, Rajiven_US
dc.contributor.authorBansal, Pranaven_US
dc.date.accessioned2020-04-23T07:58:53Z
dc.date.available2020-04-23T07:58:53Z
dc.date.issued2019-11
dc.description.abstractBackground: The objective of the study was to compare the efficacy and safety of ketoprofen patch versus diclofenac patch as post-operative analgesic in hysterectomy patients.Methods: The study was a prospective, single blind, randomized, comparative interventional clinical study conducted in a tertiary care hospital. Sixty female patients were randomly allocated to receive either ketoprofen or diclofenac patch 1 hour prior to the hysterectomy. Pain was assessed postoperatively after an interval of every four hours for 24 hours using visual analogue scale (VAS) and verbal rating scale (VRS).Results: In ketoprofen group, mean VAS was (2.92�11) significantly low as compared to diclofenac group (3.25�14). The mean VRS score in group ketoprofen (1.62�22) was low as compared to group diclofenac (1.83�16). Safety analysis revealed no apparent serious adverse events. Inj. Paracetamol 1 gm i.v was given as rescue analgesic to the patients in whom VRS >2 and VAS >5 was noted. Data were analysed using unpaired student抯 t-test.Conclusions: Transdermal patches are very convenient to use and causes less discomfort as compared to traditional routes of drug delivery. Ketoprofen patch was found better in providing analgesia after hysterectomy as compared to diclofenac patch with lesser side effects.en_US
dc.identifier.affiliationsDepartment of Pharmacology, BPS GMC (W), Khanpur Kalan, Sonepat, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, BPS GMC (W), Khanpur Kalan, Sonepat, Haryana, Indiaen_US
dc.identifier.affiliationsDepartment of Anaesthesiology, BPS GMC (W), Khanpur Kalan, Sonepat, Haryana, Indiaen_US
dc.identifier.citationRani Seema, Savant Meenakshi, Mahendru Rajiv, Bansal Pranav. Comparison of efficacy and safety of ketoprofen patch versus diclofenac patch as post-operative analgesic in hysterectomy patients. International Journal of Basic & Clinical Pharmacology. 2019 Nov; 8(11): 2445-2449en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200403
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber11en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20194781en_US
dc.subjectTransdermalen_US
dc.subjectVerbal rating scaleen_US
dc.subjectVisual analogue scaleen_US
dc.titleComparison of efficacy and safety of ketoprofen patch versus diclofenac patch as post-operative analgesic in hysterectomy patientsen_US
dc.typeJournal Articleen_US
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