Human sodium iodide symporter (hNIS) in fibroadenoma breast—A immunohistochemical study.

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dc.contributor.authorRai, Ruchi
dc.contributor.authorShrivastava, Ashutosh
dc.contributor.authorTandon, Ashwani
dc.contributor.authorGodbole, Madan M
dc.contributor.authorKumar, Sandeep
dc.contributor.authorDas, Vinita
dc.contributor.authorDwivedi, Varsha
dc.contributor.authorPal, Lily
dc.date.accessioned2013-02-13T09:56:23Z
dc.date.available2013-02-13T09:56:23Z
dc.date.issued2011-02
dc.description.abstractHuman sodium iodide symporter (hNIS), responsible for the active transport of iodine is an integral plasma membrane glycoprotein present in the thyroid cells and extrathyroid tissues like breast and salivary glands. If its functional form is unequivocally shown in benign or malignant breast tissues, then it may serve as a basis for diagnosis and treatment using radioactive iodine. With an aim to analyze the hNIS expression in a distinct benign breast condition of fibroadenoma, biopsy proven fibroadenoma tissues, normal non-lactating breast tissue and biopsy proven infiltrating duct carcinoma tissues were examined for hNIS expression using immunohistochemistry. Out of 20 biopsy proven fibroadenoma tissues, 19 (95%) showed positivity for hNIS protein and only one was negative. Of these 10% were mildly positive, 50% cases were moderately positive and 35% showed intense positivity. None of the control tissue obtained from reduction mammoplasty specimens or normal breast tissues samples (5 cms away from the tumor) were positive. hNIS was also intensely positive  in 9 out of 10 (90%) infiltrating duct carcinoma tissues and moderately positive in one case. These preliminary results show that hNIS was present in high frequency as demonstrated by immunohistochemistry in fibroadenoma breast.en_US
dc.identifier.citationRai Ruchi, Shrivastava Ashutosh, Tandon Ashwani, Godbole Madan M, Kumar Sandeep, Das Vinita, Dwivedi Varsha, Pal Lily. Human sodium iodide symporter (hNIS) in fibroadenoma breast—A immunohistochemical study. Indian Journal of Experimental Biology. 2011 Feb; 49(2): 113-117.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/145104
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/11004en_US
dc.subjectFibroadenoma breasten_US
dc.subjectHuman sodium iodide symporter (hNIS)en_US
dc.subjectImmunohistochemistryen_US
dc.titleHuman sodium iodide symporter (hNIS) in fibroadenoma breast—A immunohistochemical study.en_US
dc.typeArticleen_US
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