Hormonal modulation of biosynthesis of prostatic specific antigen, prostate specific acid phosphatase and prostatic inhibin peptide.

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dc.contributor.authorSheth, A Ren_US
dc.contributor.authorGarde, S Ven_US
dc.contributor.authorMehta, M Ken_US
dc.contributor.authorShah, M Gen_US
dc.date.accessioned2009-05-28T12:29:07Z
dc.date.available2009-05-28T12:29:07Z
dc.date.issued1992-03-01en_US
dc.description.abstractHormonal modulation of in vitro biosynthesis of three prostatic secretory proteins, prostate specific acid phosphatase (PSAP), prostate specific antigen (PSA) and prostatic inhibin peptide (PIP) by human benign hyperplasia (BPH) tissue was studied. LH and inhibins caused increase in the synthesis of all three proteins whereas FSH enhanced the synthesis of PIP and PSA only but decreased PSAP synthesis. Prolactin and thyroid releasing hormone decreased synthesis of PIP and PSAP. However, PSA synthesis was enhanced by TRH and was decreased by prolactin. Estradiol caused significant increase in PSA and PSAP but no discernible changes in PIP synthesis were noticed. Testosterone caused an increase in PIP, PSA and PSAP. These data indicate that biosynthesis of PIP, PSA and PSAP by BPH tissue is under multihormonal regulation.en_US
dc.description.affiliationInstitute for Research in Reproduction (ICMR), Bombay, India.en_US
dc.identifier.citationSheth AR, Garde SV, Mehta MK, Shah MG. Hormonal modulation of biosynthesis of prostatic specific antigen, prostate specific acid phosphatase and prostatic inhibin peptide. Indian Journal of Experimental Biology. 1992 Mar; 30(3): 157-61en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58145
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAcid Phosphatase --biosynthesisen_US
dc.subject.meshAntigens, Neoplasm --biosynthesisen_US
dc.subject.meshEstradiol --pharmacologyen_US
dc.subject.meshFollicle Stimulating Hormone --pharmacologyen_US
dc.subject.meshHormones --pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInhibins --biosynthesisen_US
dc.subject.meshLuteinizing Hormone --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshProstate --metabolismen_US
dc.subject.meshProstate-Specific Antigenen_US
dc.subject.meshTestosterone --pharmacologyen_US
dc.subject.meshThyrotropin-Releasing Hormone --pharmacologyen_US
dc.subject.meshTumor Markers, Biological --biosynthesisen_US
dc.titleHormonal modulation of biosynthesis of prostatic specific antigen, prostate specific acid phosphatase and prostatic inhibin peptide.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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