Comparison between Levobupivacaine and Levobupivacaine with Clonidine in Erector Spinae Plane Block in Patients undergoing open Cholecystectomy: A Prospective Randomized Double Blinded Study
No Thumbnail Available
Date
2025-06
Journal Title
Journal ISSN
Volume Title
Publisher
Dr. Annil Mahajan from Jammu (J&K), India
Abstract
Background: Erector spinae plane (ESP) block is effective for post-operative analgesia in thoracic and abdominal surgeries. There is minimal experience with clonidine (alpha2 agonist) as an adjuvant to levobupivacaine in ESP block. The objective of the present study is to compare the duration of postoperative analgesia between levobupivacaine and levobupivacaine with clonidine in open cholecystectomy following ESP block. Methods: One hundred patients, randomly divided into two groups, undergoing open cholecystectomy under general anaesthesia (GA), were given ESP block 20 min before administration of GA. Group L received 19 ml of 0.25% levobupivacaine with 1 ml of normal saline and group LC received clonidine (1.5 mcg/ kg) prepared in 1 ml of normal saline as adjuvant with 19 ml of 0.25% levobupivacaine for ESP block. In the postoperative period, the duration and requirement of analgesia were recorded. Results: Duration of post-operative analgesia in group LC was 595.78± 71.5 min compared to 357.2± 18.14 min in group L. (P<0.0001). The requirement of analgesic in the first 24 hours was also significantly less in group LC (P<0.0001).Conclusion: Clonidine as adjuvant with levobupivacaine in erector spinae plane block provides longer duration of analgesia and reduces analgesic requirement postoperatively without any significant adverse effects.
Description
Keywords
Adjuvant, Analgesia, Levobupivacaine, Clonidine, Erector Spinae Plane Block
Citation
Sahoo Swagatika, Chattopadhyay Suman, Datta Sagnik, Bhar Debasish, Maiti Asim Kumar . Comparison between Levobupivacaine and Levobupivacaine with Clonidine in Erector Spinae Plane Block in Patients undergoing open Cholecystectomy: A Prospective Randomized Double Blinded Study . JK Science Journal of Medical Education and Research. 2025 Jun; 27(2): 113-117