Anatomical spatial distribution of Influenza virus receptors in some poultry species raised in Egypt

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dc.contributor.authorNomir, A. G.en_US
dc.contributor.authorZidan, M. A.en_US
dc.contributor.authorElgarhy, A. K.en_US
dc.contributor.authorIbrahim, M. S.en_US
dc.contributor.authorWatanabe, Y.en_US
dc.contributor.authorArai, Y.en_US
dc.contributor.authorIkuta, K.en_US
dc.contributor.authorSharaby, A. A. E.en_US
dc.date.accessioned2019-11-16T07:14:21Z
dc.date.available2019-11-16T07:14:21Z
dc.date.issued2018
dc.description.abstractBackground: Avian influenza H5N1 has been distressing not only the poultry industry but also humans causing fatal infections in Egypt. Understanding the initial steps in the viral infection was proposed by many to be a key for solving the entire problem. Domestic healthy chicken, Pekin duck, Egyptian goose, Japanese quail, pigeon and turkey were purchased; three adult birds per each species. Lectin histochemistry was performed using fluorescein isothiocyanate labelled Sambucusnigra agglutinin specific for SAα2,6-gal receptors, and FITC labelled Maackiaamurensis agglutinins specific for SAα2,3-gal receptors. Methods: From each bird, three specimens per each trachea, lung, duodenum, colon, liver and brain were used. In chicken, duck, goose, Japanese quail, domestic pigeon and turkey, both SAα2,3-gal and SAα2,6-gal receptors were expressed in at least one segment of respiratory and intestinal tracts except in pigeons where SAα2,3-gal receptors were not expressed in the respiratory tract while in ducks were not expressed in lower respiratory tract and in turkey not expressed in small intestine. The human type receptors were not expressed in the lower trachea of goose, large intestine of chicken and intestinal tract and liver of turkey and pigeons. Results: The widespread detection of both SAα2,6-gal and SAα2,3-gal receptors in different tissues from each species suggests that these birds’ organs may be potential targets for both avian and human influenza viruses, and can act as adaptive host for avian influenza viruses to change receptor specificity. This may indicate that different native bird species in Egypt could have participated equally or variably in the generation of H5N1 viruses that were able to extensively infect humans. All experimental procedures were approved by Damanhour university ethics committee. The widespread detection of both SAα2,6-gal and SAα2,3-gal receptors in different tissues from each species suggests that these birds’ organs may be potential targets for both avian and human influenza viruses, and can act as adaptive host for avian influenza viruses to change receptor specificity. Conclusion: This may indicate that different native bird species in Egypt could have participated equally or variably in the generation of H5N1 viruses that were able to extensively infect humans.en_US
dc.identifier.affiliationsDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Damanhour University, Egypten_US
dc.identifier.affiliationsDepartment of Histology and Cytology, Faculty of Veterinary Medicine, Alexandria University, Egypten_US
dc.identifier.affiliationsDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Damanhour University, Egypten_US
dc.identifier.affiliationsDepartment of Microbiology, Faculty of Veterinary Medicine, Damanhour University, Egypten_US
dc.identifier.affiliationsDepartment of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japanen_US
dc.identifier.affiliationsDepartment of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japanen_US
dc.identifier.affiliationsDepartment of Virology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japanen_US
dc.identifier.affiliationsDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Damanhour University, Egypten_US
dc.identifier.citationNomir, A. G., Zidan, M. A., Elgarhy, A. K., Ibrahim, M. S., Watanabe, Y., Arai, Y., Ikuta, K., Sharaby, A. A. E. . Anatomical spatial distribution of Influenza virus receptors in some poultry species raised in Egypt. Academia Anatomica International. 2018 Jan-Jun; 4(1): 52-61en_US
dc.identifier.issn2455-5274
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/183658
dc.languageenen_US
dc.publisherSociety for Health Care & Research Developmenten_US
dc.relation.issuenumber1en_US
dc.relation.volume4en_US
dc.source.urihttps://doi.org/10.21276/aanat.2018.4.1.12en_US
dc.subjectInfluenzaen_US
dc.subjectVirusen_US
dc.subjectReceptoren_US
dc.subjectEgypten_US
dc.subjectpoultryen_US
dc.titleAnatomical spatial distribution of Influenza virus receptors in some poultry species raised in Egypten_US
dc.typeJournal Articleen_US
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