Antibiotic Prophylaxis Before Invasive Dental Procedures for Patients atHigh Risk of Infective Endocarditis - A Systematic Review

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dc.contributor.authorAlbakri, Arefen_US
dc.contributor.authorAhsan, Auswafen_US
dc.contributor.authorVengal, Manojen_US
dc.contributor.authorparambathu, Ashir Kolikkal Ramachamen_US
dc.contributor.authorMajeed, Abdulen_US
dc.contributor.authorSiddiq, Hananen_US
dc.date.accessioned2023-08-09T06:18:29Z
dc.date.available2023-08-09T06:18:29Z
dc.date.issued2022-12
dc.description.abstractBackground: Clinical use of antibiotics prophylaxis (AP) for preventing infective endocarditis (IE) after invasive dental procedures is controversial. Expert consensus guidelines are inconsistent, either restricting its use to high?risk individuals or advising its use again. Objectives: To determine whether there is a genuine need for AP to prevent IE in high?risk patients undergoing invasive dental procedures. Methods: Online search was performed on PubMed, Science Direct, British Dental Journal and Cochrane Register of Controlled Trials. The methodological quality of each study was assessed using the Cochrane Handbook for Systematic Reviews of Interventions. Results: Seventeen (17) clinical trials were included in the final analysis recruiting 2,410 patients (AP = 1,366; placebo = 1,044). Bacteraemia was detected in 302 AP patients (22.1%) and 362 placebo patients (34.7%). AP reduced the risk of bacteraemia by 49% (risk ratio: 0.51; 95% CI; 0.45 to 0.58; P = 0.0001). Conclusion: Although using AP for IE may be pragmatic and justified for high?risk patients undergoing invasive dental procedures, the evidence is inconclusive because post?procedural bacteraemia may not be a good surrogate marker for IE. Moreover, trials investigating the direct association between AP and IE are lacking due to low disease prevalence and high?cost challengesen_US
dc.identifier.affiliationsDepartment of Internal Medicine, St-Marien Hospital, Bonn, Venusberg, Germanyen_US
dc.identifier.affiliationsDepartment of Oral Medicine and Radiology, SKROLLS, Scientific Publishing Academy, Keralaen_US
dc.identifier.affiliationsDepartment of Oral Medicine and Radiology, KMCT Dental College, Keralaen_US
dc.identifier.affiliationsDepartment of Public Health Dentistry, Manipal College of Dental Sciences, Karnataka, Indiaen_US
dc.identifier.citationAlbakri Aref, Ahsan Auswaf, Vengal Manoj, parambathu Ashir Kolikkal Ramacham, Majeed Abdul, Siddiq Hanan. Antibiotic Prophylaxis Before Invasive Dental Procedures for Patients atHigh Risk of Infective Endocarditis - A Systematic Review. Indian Journal of Dental Research. 2022 Dec; 33(4): 452-458en_US
dc.identifier.issn1998-3603
dc.identifier.issn0970-9290
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222429
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber4en_US
dc.relation.volume33en_US
dc.source.urihttps://doi.org/10.4103/ijdr.ijdr_810_21en_US
dc.subjectAntibiotic prophylaxisen_US
dc.subjectbacterial endocarditisen_US
dc.subjectinfective endocarditisen_US
dc.subjectinvasive dental procedureen_US
dc.titleAntibiotic Prophylaxis Before Invasive Dental Procedures for Patients atHigh Risk of Infective Endocarditis - A Systematic Reviewen_US
dc.typeJournal Articleen_US
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