Benzodiazepine inverse agonist, DMCM- and peripheral agonist, Ro 5-4864-induced convulsions in mice: effect of adenosinergic agents.

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dc.contributor.authorThorat, S Nen_US
dc.contributor.authorKulkarni, S Ken_US
dc.date.accessioned2009-05-28T11:33:45Z
dc.date.available2009-05-28T11:33:45Z
dc.date.issued1990-12-01en_US
dc.description.abstractAdenosinergic agents such as adenosine, 2-chloro-adenosine, N6-cyclohexyladenosine produced dose-dependent protective effect against DMCM- and Ro 5-4864-induced convulsions and mortality. N6-cyclohexyladenosine produced most significant protective e ect against Ro 5-4864-induced convulsions whereas 2-chloroadenosine was more effective than N6-cyclohexyladenosine in antagonising DMCM-induced convulsions. Pretreatment of animals with subprotective doses of adenosine and dipyridamole significantly prolonged the latencies for the onset of myoclonic jerks and convulsions due to both DMCM and Ro 5-4864. DMCM and Ro 5-4864-induced mortality rate was also significantly reduced by pretreatment with subprotective doses of adenosine and dipyridamole. Similarly, subprotective doses of adenosine and diazepam further delayed the latencies for myoclonic jerks and convulsions due to DMCM and Ro 5-4864 treatment. The results suggest that adenosine and adenosine receptor agonists, 2-chloroadenosine and N6-cyclohexyladenosine are protective against both DMCM- and Ro 5-4864-induced convulsions. It is suggested that adenosinergic agents via activation of central A1 adenosine receptors may modulate the convulsant effects mediated by DMCM and Ro 5-4864. This study further supports the notion that adenosinergic mechanisms mediate neuroprotective e ects in the central nervous system.en_US
dc.description.affiliationDepartment of Pharmaceutical Sciences, Panjab University, Chandigarh, India.en_US
dc.identifier.citationThorat SN, Kulkarni SK. Benzodiazepine inverse agonist, DMCM- and peripheral agonist, Ro 5-4864-induced convulsions in mice: effect of adenosinergic agents. Indian Journal of Experimental Biology. 1990 Dec; 28(12): 1160-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56887
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdenosine --analogs & derivativesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBenzodiazepines --pharmacologyen_US
dc.subject.meshBenzodiazepinones --pharmacologyen_US
dc.subject.meshCarbolines --pharmacologyen_US
dc.subject.meshConvulsantsen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.titleBenzodiazepine inverse agonist, DMCM- and peripheral agonist, Ro 5-4864-induced convulsions in mice: effect of adenosinergic agents.en_US
dc.typeJournal Articleen_US
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