Production of paclitaxel by Fusarium solani isolated from Taxus celebica.

Chakravarthi, B V S K; Das, Prasanta; Surendranath, Kalpana; Karande, Anjali A; Jayabaskaran, Chelliah

Production of paclitaxel by Fusarium solani isolated from Taxus celebica.

Date

2008-06-07

Authors

Chakravarthi, B V S K

Das, Prasanta

Surendranath, Kalpana

Karande, Anjali A

Jayabaskaran, Chelliah

Abstract

A fungus was isolated from the stem cuttings of Taxus celebica, which produced paclitaxel in liquid-grown cultures. The fungus was identified as Fusarium solani based on colony characteristics, morphology of conidia and the 26S rDNA sequence. Paclitaxel was identified by chromatographic and spectroscopic comparison with authentic paclitaxel and its cytotoxic activity towards Jurkat cells in vitro.

Citation

Chakravarthi BV, Das P, Surendranath K, Karande AA, Jayabaskaran C. Production of paclitaxel by Fusarium solani isolated from Taxus celebica. Journal of Biosciences. 2008 Jun; 33(2): 259-67