Karyotypic study of chronic and blastic phase chronic myeloid leukemia patients of Gujarat State.
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Date
2010-04
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Abstract
For present work, 27 clinically diagnosed Chronic Myeloid Leukemia patients were
selected, who attended the Out Patient Department of Gujarat Cancer and Research
Institute, Ahmedabad. In all these cases relevant history, clinical findings,
haematological data and other investigations were noted & bone-marrow samples were
obtained for further study, which was done at Genetics Laboratory, B.J. Medical
College, Ahmedabad. Samples were cultured, harvested, slides were prepared &
photographs were obtained using photomicroscope and Karyotypes were prepared by
using conventional cut and paste technique. Cytogenetic evaluation was done to detect
the presence of Philadelphia chromosome and/or other chromosomal abnormalities.
Out of 27 patients studied, 22 cases were having mild to moderate & remaining 5 cases
were having huge splenomegaly. The blood picture showed, 9 were anaemic; 11 having
total leukocytic count more than 1 lakh/mm3 ; 8 cases were thrombocytopenic. 25 cases
were in chronic and 2 cases were in blastic phase. Cytogenetic evaluation by
Karyotypes revealed 13 Ph’ positive cases; 4 Ph’ negative; 3 mosaic & remaining 7
cases came out inconclusive. All relevant parameters including clinical, hematological
and cytogenetic were evaluated, analyzed and compared with other similar studies.
Description
Keywords
CML, Karyotypic study, chronic and blastic phase CML, Ph’ chromosome
Citation
Kariya V B, Trivedi D J, Srimankar P S, Pensi C A, Thakker D V. Karyotypic study of chronic and blastic phase chronic myeloid leukemia patients of Gujarat State. National Journal of Integrated Research in Medicine. 2010 Apr-Jun; 1(2): 1-5.