Evaluation of Serum Adenosine Deaminase Levels as Diagnostic Marker in Pulmonary and Extra Pulmonary Tuberculosis Cases

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dc.contributor.authorOmar, Asiaen_US
dc.contributor.authorTabrez, Md. Shamsen_US
dc.contributor.authorSingh, Sude Kumaren_US
dc.contributor.authorKumar, Ajiten_US
dc.contributor.authorSingh, Shankar Dayalen_US
dc.contributor.authorNafe, Abuen_US
dc.date.accessioned2025-05-09T11:04:42Z
dc.date.available2025-05-09T11:04:42Z
dc.date.issued2024-07
dc.description.abstractIntroduction: There is growing interest in developing biochemical tests that measure the body's metabolic reaction in tuberculosis (TB) infection. Both pulmonary and extrapulmonary TB can be diagnosed using these tests, which seems to be an appealing approach. Adenosine deaminase (ADA), an enzyme involved in purine breakdown, is present in T lymphocytes . It has been shown that tuberculosis leads to elevation in the T lymphocytes and eventually causes an elevation in ADA activity. Aim: To evaluate the diagnostic potential of serum ADA concentration in detecting pulmonary and extra pulmonary tuberculosis cases. Methods and Materials: For this study, 336 patients in a variety of age groups who were admitted were chosen. In this investigation, 112 patients of pulmonary tuberculosis were considered. This study comprised 112 cases of extra- pulmonary TB in total. This study comprised 112 control volunteers who were matched for age and sex. 46 of them served as healthy controls for this study; they had a normal skiagram chest, no previous history of pulmonary or extrapulmonary tuberculosis, and no other chronic illnesses. This study includes 66 diseased controls with empyema, pneumonia, and cancer were included. ADA was calculated using a commercial ADA-MTB kit produced by Tulip Diagnostics (P) Ltd.'s MICROXPRESS division. Results: Mean Serum ADA concentration was 45.78�33 IU/L, 27.31�21 IU/L and 14.43� 1.84 in pulmonary TB participants, diseased controls and healthy controls respectively. Mean Serum ADA concentration was 44.74�12 IU/L, 29.95�64 IU/L and 14.42 �86 in extra pulmonary TB participants, diseased controls and healthy controls respectively. It was observed that serum ADA was significantly greater in pulmonary TB and extra pulmonary TB study participants as compared to disease controls and healthy controls. (p<0.05). The overall accuracy was 95.32% in detecting pulmonary tuberculosis. The overall accuracy was 94.16% in detecting pulmonary tuberculosis. Fischer exact revealed statistically significant diagnostic ability of serum ADA concentration in identification of pulmonary TB and extra pulmonary TB. Conclusion: Serum ADA concentration can be important diagnostic tool in identification of pulmonary TB and extra pulmonary TB.en_US
dc.identifier.affiliationsFinal year PG, Department of Biochemistry, Darbhanga Medical College, Laheriasarai , Darbhangaen_US
dc.identifier.affiliationsFinal year PG, Department. of Biochemistry, Darbhanga Medical College, Laheriasarai, Darbhangaen_US
dc.identifier.affiliationsProfessor. & HEAD, Department. of Biochemistry, Darbhanga Medical College, Laheriasarai, Darbhangaen_US
dc.identifier.affiliationsSecond year PG, Dept. of Biochemistry, Darbhanga Medical College, Laheriasarai, Darbhangaen_US
dc.identifier.affiliationsFirst year PG, Department of Biochemistry, Darbhanga Medical College, Laheriasarai, Darbhangaen_US
dc.identifier.affiliationsAssociate Professor, Department of Periodontics and Implantology, M.M.Dental College and Hospital, Darbhangaen_US
dc.identifier.citationOmar Asia, Tabrez Md. Shams, Singh Sude Kumar, Kumar Ajit, Singh Shankar Dayal, Nafe Abu . Evaluation of Serum Adenosine Deaminase Levels as Diagnostic Marker in Pulmonary and Extra Pulmonary Tuberculosis Cases. International Journal of Contemporary Medical Research. 2024 Jul; 11(7): 1-6en_US
dc.identifier.issn2393-915X
dc.identifier.issn2454-7379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246173
dc.languageenen_US
dc.publisherInternational Society for Contemporary Medical Researchen_US
dc.relation.issuenumber7en_US
dc.relation.volume11en_US
dc.source.urihttps://www.ijcmr.com/uploads/7/7/4/6/77464738/ijcmr_3741.pdfen_US
dc.subjectSerum Adenosine Deaminaseen_US
dc.subjectPulmonary Tuberculosisen_US
dc.subjectExtra Pulmonary Tuberculosisen_US
dc.titleEvaluation of Serum Adenosine Deaminase Levels as Diagnostic Marker in Pulmonary and Extra Pulmonary Tuberculosis Casesen_US
dc.typeJournal Articleen_US
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