Aptamers: Trending Prospective in Therapeutics

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dc.contributor.authorKalam, Syed Abulen_US
dc.contributor.authorHashmi, Afreenen_US
dc.contributor.authorSrivastava, Pranatien_US
dc.date.accessioned2020-09-24T07:34:31Z
dc.date.available2020-09-24T07:34:31Z
dc.date.issued2020-02
dc.description.abstractAptamers are short stretches of Ribonucleic acid or Deoxyribonucleic acid having a specific 3D shape which form complexes with the target site with high affinity. Systemic Evolution of Ligands by Exponential Enrichment (SELEX) is responsible for the high affinity and specificity of aptamers to bind the target molecules. Due to some unique features of Aptamers, it attracts the attention of many scientists to use them as a tool in the treatment & diagnosis of various diseases and syndromes. The results obtained from the various clinical data shows that Aptamers can be used in the treatment and diagnosis of various diseases including cancer and syndromes like AIDS, severe acute respiratory syndrome etc. Many viral infections like human immunodeficiency virus, hepatitis B virus and Ebola virus are now treated or diagnosed with the help of aptamers. Along with viral infections, aptamers are also promising Chemical antibodies in the treatment of various kinds of cancer like breast cancer, lung cancer, colorectal cancer, etc. Aptamers have several advantages over conventional antibodies in context to its size, thermal stability, immunogenicity, ease of modification, etc. Aptamers are smaller than conventional antibodies, this property allows aptamers to access in tissue and cell. Aptamers are synthetic agents and we scale up its production as per requirement and it eliminate the various regulatory requirements associated with bio- production. The various roles of aptamers in the treatment and diagnosis of many life- threatening diseases, syndromes and viral infections like cancer, AIDS, Ebola virus lead aptamers to serve as Future Pharmaceutical dosage form or prospective Future of Modern Medical Science.en_US
dc.identifier.affiliationsAmity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, India*en_US
dc.identifier.citationKalam Syed Abul, Hashmi Afreen, Srivastava Pranati. Aptamers: Trending Prospective in Therapeutics. International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL). 2020 Feb; 8(5): 1-9en_US
dc.identifier.issn2282-0238
dc.identifier.issn2393-932X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203826
dc.languageenen_US
dc.publisherSociety for research and Development in Educationen_US
dc.relation.issuenumber5en_US
dc.relation.volume8en_US
dc.source.urihttps://doi.org/10.47128/IJRDPL.2278-%200238.2019.8(5).1-9en_US
dc.subjectSELEXen_US
dc.subjectChemical antibodyen_US
dc.subjectChronic diseasesen_US
dc.subjectBio-productionen_US
dc.subjectTargetingen_US
dc.titleAptamers: Trending Prospective in Therapeuticsen_US
dc.typeJournal Articleen_US
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