Sequential enhanced tyrosine phosphorylation during progressive malachite green induced malignant transformation of Syrian hamster embryo cells in culture is associated with no change in the activity levels of tyrosine phosphatases.

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dc.contributor.authorMahudawala, D Men_US
dc.contributor.authorRao, K Ven_US
dc.date.accessioned2009-05-28T14:31:39Z
dc.date.available2009-05-28T14:31:39Z
dc.date.issued1999-05-24en_US
dc.description.abstractMalachite green (MG) consisting green crystals with a metallic lustre is extremely soluble in water and is highly cytotoxic to mammalian cells and also acts as liver tumor promoter. In view of its industrial importance and possible exposure to human beings, MG poses a potential environmental health hazard. We have earlier reported that MG induces malignant transformation in Syrian hamster embryo (SHE) cells. Since tyrosine phosphorylation and dephosphorylation reactions are known to play critical roles during normal and abnormal cellular proliferation, in this study we have studied the tyrosine phosphorylation, tyrosine phosphorylated proteins and protein tyrosine phosphatases in malignantly transformed cells and during sequential development of cellular transformation by MG compared to control cells. The present investigation shows that enhanced tyrosine phosphorylation and tyrosine phosphorylated proteins associated with the static levels of tyrosine protein phosphatases may probably contribute to the abnormal cellular proliferation during malignant transformation of SHE cells by MG.en_US
dc.description.affiliationCellular Carcinogenesis Laboratory, Tata Memorial Centre, Mumbai, India.en_US
dc.identifier.citationMahudawala DM, Rao KV. Sequential enhanced tyrosine phosphorylation during progressive malachite green induced malignant transformation of Syrian hamster embryo cells in culture is associated with no change in the activity levels of tyrosine phosphatases. Indian Journal of Experimental Biology. 1999 May; 37(5): 423-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60824
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCell Transformation, Neoplasticen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshElectrophoresis, Polyacrylamide Gelen_US
dc.subject.meshHumansen_US
dc.subject.meshMesocricetusen_US
dc.subject.meshPhosphorylationen_US
dc.subject.meshProtein Tyrosine Phosphatases --metabolismen_US
dc.subject.meshProtein-Tyrosine Kinases --metabolismen_US
dc.subject.meshRosaniline Dyesen_US
dc.subject.meshTyrosine --metabolismen_US
dc.titleSequential enhanced tyrosine phosphorylation during progressive malachite green induced malignant transformation of Syrian hamster embryo cells in culture is associated with no change in the activity levels of tyrosine phosphatases.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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