Inhibition of angiogenic attributes by decursin in endothelial cells and ex vivo rat aortic ring angiogenesis model.

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dc.contributor.authorBhat, Tariq A
dc.contributor.authorMoon, Jung S
dc.contributor.authorLee, Sookyeon
dc.contributor.authorYim, Dongsool
dc.contributor.authorSingh, Rana P
dc.date.accessioned2013-02-22T04:00:33Z
dc.date.available2013-02-22T04:00:33Z
dc.date.issued2011-11
dc.description.abstractThe present study was undertaken to observe the inhibition of angiogenesis by decursin. It was the first time to show that decursin offered strong anti-angiogenic activities under the biologically relevant growth (with serum) conditions. Decursin significantly inhibited human umbilical vein endothelial cell (HUVEC) proliferation concomitant with G1 phase cell cycle arrest. Decursin also inhibited HUVEC-capillary tube formation and invasion/migration in a dose-dependant manner which was associated with the suppression of matrix metalloproteinase (MMP) -2 and -9 activities. Decursin suppressed angiogenesis in ex vivo rat aortic ring angiogenesis model where it significantly inhibited blood capillary-network sprouting from rat aortic sections. Taken together, these findings suggested anti-angiogenic activity of decursin in biologically relevant condition, and warrants further pre-clinical studies for its potential clinical usefulness.en_US
dc.identifier.citationBhat Tariq A, Moon Jung S, Lee Sookyeon, Yim Dongsool, Singh Rana P. Inhibition of angiogenic attributes by decursin in endothelial cells and ex vivo rat aortic ring angiogenesis model. Indian Journal of Experimental Biology. 2011 Nov; 49(11): 848-856.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/145201
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/13002en_US
dc.subjectAngiopreventionen_US
dc.subjectDecursinen_US
dc.subjectTumor angiogenesisen_US
dc.titleInhibition of angiogenic attributes by decursin in endothelial cells and ex vivo rat aortic ring angiogenesis model.en_US
dc.typeArticleen_US
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