Comparison of Thymus vulgaris (Thyme), Achillea millefolium (Yarrow) and propolis hydroalcoholic extracts versus systemic glucantime in the treatment of cutaneous leishmaniasis in balb/c mice.

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dc.contributor.authorNilforoushzadeh, M Aen_US
dc.contributor.authorShirani-Bidabadi, Len_US
dc.contributor.authorZolfaghari-Baghbaderani, Aen_US
dc.contributor.authorSaberi, Sen_US
dc.contributor.authorSiadat, A Hen_US
dc.contributor.authorMahmoudi, Men_US
dc.date.accessioned2008-12-03en_US
dc.date.accessioned2009-06-02T15:54:34Z
dc.date.available2008-12-03en_US
dc.date.available2009-06-02T15:54:34Z
dc.date.issued2008-12-03en_US
dc.description.abstractBACKGROUND & OBJECTIVES: Leishmaniasis is a parasitic disease transmitted by sand flies. Many investigations are performed to find an effective and safe treatment for leishmaniasis. In this study, we evaluated the efficacy of herbal extracts of Thymus vulgaris (Thyme) and Achillea millefolium (Yarrow), propolis hydroalcoholic extract and systemic glucantime against cutaneous leishmaniasis in Balb/c mice. METHODS: A total of 45 mice were randomised into five groups each including nine mice. They were treated with pure ethanol 70 degrees, systemic glucantime, Achillea millefolium hydroalcoholic extract, Thymus vulgaris hydroalcoholic extract and propolis hydroalcoholic extract for six weeks. The statistical tests including student t-test were used for analysis. Data were analyzed by SPSS software, ver 13.00. RESULTS: Mean of ulcer size reduction were -17.66, -22.57, 43.29, 36.09 and 43.77% for the alcohol, glucantime, yarrow, thyme and propolis groups, respectively. The results were suggestive that Thymus vulgaris, Achillea millefolium and propolis hydroalcoholic extracts were significantly more effective in reduction of ulcer size as compared with glucantime (p = 0.006, 0.002 and 0.008, respectively). INTERPRETATION & CONCLUSION: Our results are suggestive that Thymus vulgaris, Achillea millefolium and propolis extracts are effective for treatment of cutaneous leishmaniasis in mice. Regarding these results, we suggest that efficacy of these extracts alone or in combination are evaluated against human cutaneous leishmaniasis as a randomized clinical trial.en_US
dc.description.affiliationSkin Diseases and Leishmaniasis Research Center (Sedigheh Tahereh), Isfahan University of Medical Sciences, Isfahan, Iran.en_US
dc.identifier.citationNilforoushzadeh MA, Shirani-Bidabadi L, Zolfaghari-Baghbaderani A, Saberi S, Siadat AH, Mahmoudi M. Comparison of Thymus vulgaris (Thyme), Achillea millefolium (Yarrow) and propolis hydroalcoholic extracts versus systemic glucantime in the treatment of cutaneous leishmaniasis in balb/c mice. Journal of Vector Borne Diseases. 2008 Dec; 45(4): 301-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/118067
dc.language.isoengen_US
dc.source.urihttps://www.mrcindia.org/journal/en_US
dc.subject.meshAchilleaen_US
dc.subject.meshAdministration, Cutaneousen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntiprotozoal Agents --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshInjections, Intraperitonealen_US
dc.subject.meshLeishmaniasis, Cutaneous --drug therapyen_US
dc.subject.meshMeglumine --administration & dosageen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred BALB Cen_US
dc.subject.meshOrganometallic Compounds --administration & dosageen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Extracts --administration & dosageen_US
dc.subject.meshPropolis --administration & dosageen_US
dc.subject.meshThymus Planten_US
dc.subject.meshTreatment Outcomeen_US
dc.titleComparison of Thymus vulgaris (Thyme), Achillea millefolium (Yarrow) and propolis hydroalcoholic extracts versus systemic glucantime in the treatment of cutaneous leishmaniasis in balb/c mice.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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