Evaluation of InBios Scrub Typhus Detect IgM Rapid Test in acute fever cases from Southwest and East India
No Thumbnail Available
Date
2024-12
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer – Medknow
Abstract
Background & objectives: Scrub typhus is clinically undifferentiated from other aetiologies for acute febrile illness such as enteric fever, dengue, malaria, and leptospirosis. Rapid ELISA tests are being used as an alternative to im- munofluorescence assay in tropical countries. Methods: In this study, we compared and evaluated commercially available InBios Scrub Typhus Detect IgM Rapid Test (USA) for diagnosing human scrub typhus infection using archived and prospectively collected samples against the reference standard, InBios Scrub Typhus Detect IgM ELISA (USA). Results: The data analysis of archived samples on rapid test revealed a moderate sensitivity of 53.92% and a speci- ficity of 100%. Meanwhile, prospective serum samples demonstrated higher sensitivity and specificity of 96.4% and 94.6%, respectively. Interpretation & conclusion: The InBios Scrub Typhus Detect IgM rapid test can be a good point-of-care assay during surveillance, outbreak investigations, and case identification.
Description
Keywords
Evaluation, Scrub typhus, Orientia tsutsugamushi, InBios Scrub Typhus Detect IgM RDT, InBios Scrub Typhus Detect IgM ELISA
Citation
Punekar Madhura, Jayaram Anup, Varamballi Prasad, Oliver Dsa, Sabeena Sasidharanpillai. Evaluation of InBios Scrub Typhus Detect IgM Rapid Test in acute fever cases from Southwest and East India. Journal of Vector Borne Diseases. 2024 Dec; 61(4): 587-593