Sorbitan ester niosomes for topical delivery of rofecoxib.

dc.contributor.authorDas, Malay K
dc.contributor.authorPalei, Narahari N
dc.date.accessioned2013-02-15T07:09:55Z
dc.date.available2013-02-15T07:09:55Z
dc.date.issued2011-06
dc.description.abstractThe aim of the present investigation is to encapsulate rofecoxib in niosomes and incorporate the prepared niosomes into dermal gel base for sustained therapeutic action. Niosomes were prepared by lipid film hydration technique and were analyzed for size, entrapment efficiency and drug retention capacity. Niosomal vesicles were then incorporated into blank carbopol gel to form niosomal gel. The in vitro permeation study across pig skin was performed using Keshary-Chien glass diffusion cell. The size and entrapment efficiency of the niosomal vesicles increased with gradual increase in HLB value of nonionic surfactants used. Maximum drug entrapment was observed with Span 20 with HLB value of 8.6 and drug leakage from vesicles was less at refrigerated condition than at the room temperature. Higher proportion of cholesterol made the niosomal formulation more stable with high drug retention properties. The niosomal gel showed a prolong drug release behavior compared to plain drug gel. Differential scanning calorimetric study of drug loaded gel and pig skin after permeation study confirmed inertness of carbopol gel base toward rofecoxib and absence of drug metabolism in the skin during permeation study, respectively. The niosomal formulations were successfully prepared by lipid film hydration technique using cholesterol and Span as nonionic surfactant. Presence of cholesterol made niosomes more stable with high drug entrapment efficiency and retention properties. The lower flux value of niosomal gel as compared to plain drug gel across pig skin assured the prolong drug release behavior with sustained action.en_US
dc.identifier.citationDas Malay K, Palei Narahari N. Sorbitan ester niosomes for topical delivery of rofecoxib. Indian Journal of Experimental Biology. 2011 June; 49(6): 438-445.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/145147
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/11742en_US
dc.subjectLipid film hydration techniqueen_US
dc.subjectNiosomal gelen_US
dc.subjectNiosomesen_US
dc.subjectRofecoxiben_US
dc.subjectTopical deliveryen_US
dc.titleSorbitan ester niosomes for topical delivery of rofecoxib.en_US
dc.typeArticleen_US
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