Radiosensitization of a mouse melanoma by withaferin A: in vivo studies.

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dc.contributor.authorDevi, P Uen_US
dc.contributor.authorKamath, Ren_US
dc.contributor.authorRao, B Sen_US
dc.date.accessioned2009-05-28T13:03:27Z
dc.date.available2009-05-28T13:03:27Z
dc.date.issued2000-05-29en_US
dc.description.abstractThe radiosensitizing effect of a plant withanolide, withaferin A, on the B16F1 mouse melanoma was studied in vivo. Treatment of 100 mm3 tumours with 10 to 60 mg/kg withaferin A intraperitoneally produced a dose dependent increase in growth delay and volume doubling time. Injection of 30-50 mg/kg withaferin A, followed by 30 Gy local gamma irradiation, significantly enhanced the tumour response. No systemic or local adverse reactions were noted in these groups. The drug was most effective when injected intraperitoneally 1 h before irradiation. However, neither the individual agents nor their combination could produce any complete response (tumour cure). Melanoma is a relatively radioresistant tumour. The present results indicate that the radiation response of this tumour can be significantly enhanced by pretreatment with withaferin A.en_US
dc.description.affiliationDepartment of Radiobiology, Kasturba Medical College, Manipal 576 119, India.en_US
dc.identifier.citationDevi PU, Kamath R, Rao BS. Radiosensitization of a mouse melanoma by withaferin A: in vivo studies. Indian Journal of Experimental Biology. 2000 May; 38(5): 432-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58905
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic Agents, Phytogenic --pharmacologyen_US
dc.subject.meshErgosterol --analogs & derivativesen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMelanoma, Experimental --drug therapyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57BLen_US
dc.subject.meshRadiation Tolerance --drug effectsen_US
dc.subject.meshRadiation-Sensitizing Agents --pharmacologyen_US
dc.titleRadiosensitization of a mouse melanoma by withaferin A: in vivo studies.en_US
dc.typeJournal Articleen_US
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