Influence of fenvalerate and quercetin on hepatic antioxidant enzymes.
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Date
2012-07
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Abstract
Pyrethroids are a class of neurotoxic pesticides with high selectivity for insects. Fenvalerate is a
synthetic pyrethroid pesticide used to protect a variety of crops. Fenvalerate has been reported to exert deleterious
effects on non target organisms including mammals. Recently, Fenvalerate was reported to cause liver damage in rats
probably by generating oxidative stress while Quercetin, a potential antioxidant, has been reported to posses
hepatoprotective activity. Therefore, the aim of the present investigation was to assess the ability of Quercetin to
protect liver from Fenvalerate induced toxicity. In the present investigation an effort was made to evaluate the effect of
Quercetin and Fenvalerate on hepatic G 6PD, GST and GR. Fenvalerate administration demonstrated significant
reduction in the activities of hepatic G-6-PD, GST and GR while rats co treated with Quercetin showed significant
recovery in the activities of these antioxidant enzymes.
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Keywords
Quercetin, Fenvalerate, Hepatotoxicity, Oxidative stress, Antioxidant enzymes Abbreviations: Glutathione reductase, GR, Glutathione S-transferase, GST, Glucose-6-Phosphate Dehydrogenase, G-6-PDH
Citation
Waheed M P Ashar, Mohammed H S Muthu. Influence of fenvalerate and quercetin on hepatic antioxidant enzymes. International Journal of Applied Biology and Pharmaceutical Technology. 2012 Jul-Sept; 3(3): 265-269.