Genome-wide analysis of various paralogs of aminopeptidase N (APN) gene in Anopheles gambiae (Diptera: Culicidae)

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dc.contributor.authorJakhar, Renuen_US
dc.contributor.authorGill, Rituen_US
dc.contributor.authorGakhar, Surender Kumaren_US
dc.date.accessioned2020-10-16T08:50:15Z
dc.date.available2020-10-16T08:50:15Z
dc.date.issued2019-11
dc.description.abstractMalaria continues to be a life threatening infectious disease throughout the tropical region of the world.aminopeptidase N1 (APN1) is one of the best choices for developing new Malaria Transmission-blockingvaccines. In this study an attempt has been made to overview genome-wide identification of APN genes inAnopheles gambiae. A total of eighteen A. gambiae APN sequences were found that contain conserved HEXXHand GAMEN signature sequences, indicate that large numbers of APN isomers present in mosquitoes. MultipleAPN paralogs exist as a gene cluster may propose that huge synthesis of APNs is required for rapid digestion ofpeptides over a brief period. Gene structure study shows high sequence variations among them. Protein–proteininteractions show that APN1 is highly connected protein, supporting their role as hub with other five types ofAPNs involved in glutathione metabolism, act as hub protein and disruption of one of these proteins may affectthe whole pathwayen_US
dc.identifier.affiliationsCentre for Medical Biotechnology, Maharshi Dayanand University, Rohtak, Indiaen_US
dc.identifier.affiliationsCentre for Biotechnology, Maharshi Dayanand University, Rohtak, Indiaen_US
dc.identifier.affiliationsCentre for Medical Biotechnology, Maharshi Dayanand University, Rohtak, Indiaen_US
dc.identifier.citationJakhar Renu, Gill Ritu, Gakhar Surender Kumar. Genome-wide analysis of various paralogs of aminopeptidase N (APN) gene in Anopheles gambiae (Diptera: Culicidae). Journal of Applied Biology & Biotechnology. 2021 Nov; 2021 Nov: 15-24en_US
dc.identifier.issn2455-7005
dc.identifier.issn2347-212X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/209853
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber6en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org//10.7324/JABB.2019.70603en_US
dc.subjectAnopheles gambiaeen_US
dc.subjectaminopeptidase Nen_US
dc.subjectparalogous geneen_US
dc.subjectgenomeen_US
dc.subjectmultigeneen_US
dc.subjectevolutionen_US
dc.titleGenome-wide analysis of various paralogs of aminopeptidase N (APN) gene in Anopheles gambiae (Diptera: Culicidae)en_US
dc.typeJournal Articleen_US
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