The Relationship of eNOS, p22 phox, CETP and ESR1 Gene Polymorphisms Related to Endocrine-Metabolic Parameters and Metabolic Syndrome in Postmenopausal Women - A Sample Population Based Study.

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dc.contributor.authorIanas, Olga
dc.contributor.authorManda, Dana
dc.contributor.authorRosca, Roxana
dc.contributor.authorVladoiu, Susana
dc.contributor.authorOros, Sabina
dc.contributor.authorPopa, Oana
dc.contributor.authorCovic, Marcela
dc.contributor.authorHeltianu, Constantina
dc.contributor.authorSima, Anca
dc.contributor.authorSavu, Lorand
dc.contributor.authorGiurcaneanu, Mihaela
dc.contributor.authorDumitrache, Constantin
dc.date.accessioned2017-02-06T12:23:59Z
dc.date.available2017-02-06T12:23:59Z
dc.date.issued2016
dc.description.abstractAims: To investigate the endocrine-metabolic changes in postmenopausal women with MetS and examine relationship with the polymorphisms of eNOS-G894T, p22(phox)-930 A/G, CETP TaqIB, ESR1 (PvuII and XbaI) genes. Methods: 280 postmenopausal apparently healthy women aged between 60 and 80 years were classified into non-MetS (212) and MetS (68). Clinical, anthropometric and endocrine-metabolic parameters were measured. The single nucleotide polymorphisms were determined and tested for interacting with these parameters. Results: The weight, waist circumference, blood pressure, WBC, triglycerides, LDL-C, TG/HDL-C ratio, apolipoprotein (apo)B, apoB/apoA-I ratio, fasting glucose, insulin, HOMA, uric acid, were higher and HDL-C was lower in MetS group thus fulfilled the criteria for the MetS. The significant higher levels of E2, T3, GHBP, PTH and lower levels of cortisol, SHBG, FSH, LH, IGFBP1, cortisol/DHEA ratio were also detected. Genetic association studies showed that presence of A allele p22phoxA/G (OR=1.62; CI=1.08-2.42) and heterozygote AG-XbaI(ESR1) (OR=2.29; CI= 1.19-4.37) indicated a significant risk for MetS. The binary logistic regression (MetS vs Controls) showed an interaction of G894TeNOS polymorphism with MetS (OR>2.5; 95% CI =1.47-4.90) that associated with SBP, TG, apoB, uric acid, ASTGOT (OR>1) and HDL-C (OR<1). CETP TaqIB polymorphism associated with MetS (OR<1) in presence of SBP, GLU, TG with OR>1. ESR1 PvuII (T/C) associated with MetS (OR between 1.59-8.60) in presence of LDL-C, TG/HDL-C ratio, P with OD>1 and HDL-C, androstenedione, SHBG, FAI with OR<1. In MetS group the carriers of -TT (eNOS-G894T) genotype had higher levels of blood pressure, glucose; -GG (p22phox A/G) had higher levels of BMI, apoB/apoA ratio; -B1B2 (CETP B1/B2) had higher levels of SBP, glucose, cholesterol, HDL-C, CRP, GHBP and lower levels of TSH; -CC (PvuII) and GG (XbaI) ESR1 genotypes showed higher levels of glucose. Conclusions: These results sustain an interaction between the studied polymorphisms and the endocrine-metabolic changes in MetS pathogenesis.en_US
dc.identifier.citationIanas Olga, Manda Dana, Rosca Roxana, Vladoiu Susana, Oros Sabina, Popa Oana , Covic Marcela, Heltianu Constantina, Sima Anca, Savu Lorand, Giurcaneanu Mihaela, Dumitrache Constantin. The Relationship of eNOS, p22 phox, CETP and ESR1 Gene Polymorphisms Related to Endocrine-Metabolic Parameters and Metabolic Syndrome in Postmenopausal Women - A Sample Population Based Study. British Journal of Medicine and Medical Research. 2016; 15(7):1-17.en_US
dc.identifier.issn2231-0614
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/183106
dc.language.isoenen_US
dc.source.urihttps://www.sciencedomain.org/abstract/14466en_US
dc.subjectGenetic polymorphismsen_US
dc.subjectpostmenopausal womenen_US
dc.subjectmetabolic syndromeen_US
dc.subjecthormonal and metabolic parametersen_US
dc.titleThe Relationship of eNOS, p22 phox, CETP and ESR1 Gene Polymorphisms Related to Endocrine-Metabolic Parameters and Metabolic Syndrome in Postmenopausal Women - A Sample Population Based Study.en_US
dc.typeArticleen_US
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