Aluminum ingestion alters behaviour and some neurochemicals in rats.

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dc.contributor.authorLal, Ben_US
dc.contributor.authorGupta, Aen_US
dc.contributor.authorGupta, Aen_US
dc.contributor.authorMurthy, R Cen_US
dc.contributor.authorAli, M Men_US
dc.contributor.authorChandra, S Ven_US
dc.date.accessioned2009-05-28T12:28:29Z
dc.date.available2009-05-28T12:28:29Z
dc.date.issued1993-01-01en_US
dc.description.abstractEffect of aluminum (Al) has been investigated on the brain of rats exposed to this metal (500 mg Al/liter in drinking water) daily for 180 days. A significant reduction in the spontaneous locomotor activity was noticed after 90 and 180 days of Al exposure to the rats, the magnitude of the change being almost identical at both the time intervals. Aluminum exposure also produced significant deficits in acquisition and retention of learned response in active avoidance situation, these changes being time dependent. A significant retardation of the extinction of the learned task was noted in Al exposed rats especially at 180 days. There was significant increase in the lipid peroxidation and decrease in the activity of Mg(2+)-ATPase and Na+,K(+)-ATPase in the brain of rats at 180 days after Al exposure. The increase in the contents of the metal was maximum in rest of the brain region (87% of control) followed by hippocampus and cerebral cortex (59% of controls), cerebellum and corpus striatum (43% and 44% of controls, respectively) after 180 days. Whether Al is responsible to initiate neurotoxic effects by producing changes in the structure and function of the plasma membrane needs further investigations.en_US
dc.description.affiliationNeurotoxicology Division, Industrial Toxicology Research Centre, Lucknow, India.en_US
dc.identifier.citationLal B, Gupta A, Gupta A, Murthy RC, Ali MM, Chandra SV. Aluminum ingestion alters behaviour and some neurochemicals in rats. Indian Journal of Experimental Biology. 1993 Jan; 31(1): 30-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/58131
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdenosine Triphosphatases --metabolismen_US
dc.subject.meshAluminum --pharmacokineticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBehavior, Animal --drug effectsen_US
dc.subject.meshBrain --drug effectsen_US
dc.subject.meshLearning --drug effectsen_US
dc.subject.meshLipid Peroxidation --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.titleAluminum ingestion alters behaviour and some neurochemicals in rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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