Phytochemical and Antimicrobial Study on the Leaf Extract of Tapinanthus dodoneifolius (Van Teigh) Loranthaceae

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dc.contributor.authorM., Mohammeden_US
dc.contributor.authorA. Y., Idrisen_US
dc.contributor.authorI., Ganduen_US
dc.contributor.authorU. M., Tankoen_US
dc.contributor.authorA., Muhammaden_US
dc.contributor.authorAdeiza, A. Aen_US
dc.date.accessioned2020-10-16T08:52:18Z
dc.date.available2020-10-16T08:52:18Z
dc.date.issued2019-04
dc.description.abstractLeaves of Tapinanthus dodoneifoliusis used as traditional medicine for the treatment of menstrual pain, wound, gonorrhea, and control of diarrhea and dysentery which was extracted by cold maceration in methanol. The concentrated methanol extract was subsequently partitioned with petroleum ether, chloroform, ethylacetate and n-butanol. Agar wellDiffusion method was used to determine the antimicrobial activities of the extracts against Staphylococcus aureaus,Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Klebsiela pneumonia,Salmmnella typhi, Streptococcus pyogenes, Candida krusei, Candida tropicalis,andCandida albicanat different concentrations. Antimicrobial sensitivity test indicated that,the extract inhibited the growth of all microorganisms to varying degrees except Pseudomonas aeruginosaandCandida kruseirespectively. The in vitroantimicrobial screening revealed that, the extracts exhibited diverse activities against different microbe’s concentrations ranging from 2.5mg/ml-5mg/ml. The plant extract was found to contain flavonoids, terpenoids, saponins, tannins and cardiac glycosides which may be responsible for its antimicrobial properties. The result justifies the traditional use of the plant leaf in the treatment of menstrual pain, sexual transmitted diseases, wounds and control of dysentery and diarrhea Aims: This study was aimed at investigating the antihyperglycemic effect of a combined extract of Vernonia amygdalinaand croton zabensicuscompare with a hypoglycemic drug, glibenclamide.Methodology:Twenty 20 experimental animals were used (albino rats); the rats were divided equally into four groups of five rats each; namely A (control), B (glibenclamide 10mg/kg body weight), C (synergetic treatment 1000mg/kg body weight), D (synergetic treatment 500mg/kg of body weight). Diabetes was induced intraperitoneal using Alloxan Monohydrate to all the animals and their blood glucose rise above 200mg/dl.Results:It was observed that group B and group C treated with glibenclamide (10mg/kg body weight) and synergetic aqueous extract (1000mg/kg body weight) show significantdecrease in theen_US
dc.identifier.affiliationsNational Research Institute for Chemical Technology, P.M.B1052 Zaria, Nigeriaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Science, Ahmadu Bello University,Zaria, Nigeriaen_US
dc.identifier.affiliationsNational Research Institute for Chemical Technology, P.M.B1052 Zaria, Nigeriaen_US
dc.identifier.affiliationsDepartment of Chemistry Facultyof Science, Ibrahim Badamasi Babangida University, Lapai, Niger State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Basic Science, College of Agriculture and Animal Science,Ahmadu Bello University, Mando Road, Kaduna, Nigeriaen_US
dc.identifier.affiliationsDepartment of Animal Health and Husbandary, College of Agriculture and AnimalScience, Ahmadu Bello University, P.M.B. 2134Mando Road, Kaduna, Nigeria.en_US
dc.identifier.citationM. Mohammed, A. Y. Idris, I. Gandu, U. M. Tanko, A. Muhammad, Adeiza A. A. Phytochemical and Antimicrobial Study on the Leaf Extract of Tapinanthus dodoneifolius (Van Teigh) Loranthaceae. Journal of Advances in Medicine and Medical Research. 2019 Apr; 29(5): 1-9en_US
dc.identifier.issn2456-8899
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210088
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber5en_US
dc.relation.volume29en_US
dc.source.urihttps://dx.doi.org//10.9734/JAMMR/2019/v29i530090en_US
dc.subjectTapinanthus dodoneifoliusen_US
dc.subjectphytochemistryen_US
dc.subjectantimicrobial activityen_US
dc.titlePhytochemical and Antimicrobial Study on the Leaf Extract of Tapinanthus dodoneifolius (Van Teigh) Loranthaceaeen_US
dc.typeJournal Articleen_US
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