A comparative study of Widal test and Typhidot (IgM and IgG specific assay) test in the diagnosis of enteric fever

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dc.contributor.authorDinkar, Jyoti Kumaren_US
dc.contributor.authorKumar, Nareshen_US
dc.contributor.authorChandrakishore.en_US
dc.date.accessioned2019-12-02T09:58:52Z
dc.date.available2019-12-02T09:58:52Z
dc.date.issued2017
dc.description.abstractBackground: Enteric fever (Typhoid fever) is a common systemic infectious disease worldwide, especially in developing countries like India and continues to be one of the leading causes of morbidity and mortality. It is caused by the bacterium Salmonella typhi or Salmonella paratyphi serotypes A, B and C. The clinical diagnosis of Enteric fever traditionally depends on Blood culture and Widal tests. However limitations such as longer time for Blood culture results and difficulties in the interpretation of Widal tests make them unpractical for screening patients in endemic regions and lead to misdiagnosis and missed diagnosis. Aim and objectives: Purpose of the study was to compare the sensitivity and specificity of Widal test and Typhidot based IgM and IgG assay with the Blood culture (taken as gold standard) in the diagnosis of Enteric fever. Materials and methods: This comparative study was done on 120 patients in the General Medicine Department of Indira Gandhi Institute of Medical Sciences, Patna. All patients above 11 years of age of either sex with acute febrile illness suspected to have Enteric fever were included in this study. Febrile patients with other diagnosis were excluded. Blood culture, Widal test, Typhidot (IgM and IgG) test and other routine investigations were performed in all patients. Typhidot tests and Widal tests were compared for sensitivity and specificity. Results: Out of 120 clinically diagnosed cases of Enteric fever, 18(15%) patients were Blood culture positive for Salmonella typhi, 27(22.5%) patients were positive on Widal tests and 36(30%) were Typhidot positive. Out of 18 Blood culture positive patients for Salmonella typhi, 10 patients were Jyoti Kumar Dinkar, Naresh Kumar, Chandrakishore. A comparative study of Widal test and Typhidot (IgM and IgG specific assay) test in the diagnosis of enteric fever. IAIM, 2017; 4(7): 126-130. Page 127 positive and 8 were negative on Widal testing. Out of 36 Typhidot positive patients 16 patients were positive and 20 were negative on Blood culture. Conclusions: Traditionally Blood culture and Widal test are used in the diagnosis of Enteric fever. However Typhidot (IgM & IgG assay) tests are simple and rapid screening tests that simultaneously detect and differentiate between IgM and IgG antibody to Salmonella typhi and paratyphi produced in response to infection, thus aiding in determination of current or previous exposure. It offers the advantage of early and rapid diagnosis and helps in early institution of therapy. Preliminary data have shown sensitivity and specificity of 95% and 86% respectively of Typhidot tests.en_US
dc.identifier.affiliationsM.D. (General Medicine), FCGP, Senior Resident, Department of General Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, Indiaen_US
dc.identifier.affiliationsProfessor and HOD, Department of General Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India, nareshdr91@gmail.comen_US
dc.identifier.affiliationsM.D. (General Medicine),Senior Resident, Department of General Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, Indiaen_US
dc.identifier.citationDinkar Jyoti Kumar, Kumar Naresh, Chandrakishore.. A comparative study of Widal test and Typhidot (IgM and IgG specific assay) test in the diagnosis of enteric fever. International Archives of Integrated Medicine. 2017 Jul; 4(7): 126-130en_US
dc.identifier.issn2394-0026
dc.identifier.issn2394-0034
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/186611
dc.languageenen_US
dc.publisherEducational Society for Excellenceen_US
dc.relation.issuenumber7en_US
dc.relation.volume4en_US
dc.subjectEnteric feveren_US
dc.subjectWidal testen_US
dc.subjectTyphidot testen_US
dc.subjectBlood cultureen_US
dc.subjectSalmonella typhien_US
dc.titleA comparative study of Widal test and Typhidot (IgM and IgG specific assay) test in the diagnosis of enteric feveren_US
dc.typeJournal Articleen_US
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