Antifungal Activity of Roots Barks Extract of Securinega virosa (Roxb. ex Willd.) Baill and Anogeissus leiocarpa (DC.) Guill. & Perr, Two Plants Used in the Traditional Treatment of Candidiasis in Northern Côte d'Ivoire.
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Date
2015
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Abstract
Aims: To evaluate the anticandidal activity of some solvent extracts of Securinega virosa and
Anogeissus leiocarpa from northern Côte d'Ivoire.
Study Design: In vitro assay of antifungal activity.
Place and Duration of Study: Biochemical Pharmacodynamy Laboratory, Biosciences
Department, University Félix Houphouët-Boigny and Bacteriology-Virology Laboratory University
Hospital of Treichville, Côte d’Ivoire between January and December 2013.
Methods: The herbs studied were examined for diameter of inhibition zone using agar well
diffusion method; minimal inhibitory concentration (MIC) and minimal fungicidal concentration
(MFC) using microdilution method.
Results: All tested plants extracts, except the aqueous extracts, showed varying zones of inhibition
against fungi tested. The diameters of inhibition zones for all organic extracts are greater than 10
mm for a sample concentration of 500 mg/ml and were significantly higher than for nystatine (p
<0.05; p <0.01). The ethanol extract of Anogeissus leiocarpa revealed the strongest anticandidal
activity against all tested strains with MICs ranging from 0.195 to 12.5 mg/ml, and MFCs from 0.390
to 50 mg/ml. The phytochemical screening of extracts shows the presence of polyterpenes and
sterols, polyphenols, flavonoids, catechin tannins and alkaloids.
Conclusion: S. virosa and A. leiocarpa possesse compounds with good anticandidal properties.
This results support their traditional use in treatment of infectious diseases caused by certain
Candida species.
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Keywords
Anogeissus leiocarpa, Securinega virosa, anticandidal activity, northern Côte d'Ivoire
Citation
Adrien Kouangbé Mani, Calixte Bahi, Honoré Tia, Lucien Boga Gogo, Vincent Edoh, Joseph Djaman Allico, David N’Guessan Jean. Antifungal Activity of Roots Barks Extract of Securinega virosa (Roxb. ex Willd.) Baill and Anogeissus leiocarpa (DC.) Guill. & Perr, Two Plants Used in the Traditional Treatment of Candidiasis in Northern Côte d'Ivoire. International Journal of Biochemistry Research & Review 2015 8(1): 1-11.