Evaluation of methanolic extract of Ficus platyphylla on gastrointestinal activity.

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dc.contributor.authorAmos, Sen_US
dc.contributor.authorBinda, Len_US
dc.contributor.authorChindo, Ben_US
dc.contributor.authorAkah, Pen_US
dc.contributor.authorAbdurahman, Men_US
dc.contributor.authorDanmallam, H Uen_US
dc.contributor.authorWambebe, Cen_US
dc.contributor.authorGamaniel, Ken_US
dc.date.accessioned2009-05-28T12:20:00Z
dc.date.available2009-05-28T12:20:00Z
dc.date.issued2001-01-15en_US
dc.description.abstractMethanolic extract of Ficus platyphylla was tested on isolated rabbit jejunum, rat duodenum and gastrointestinal motility in mice. The extract showed a biphasic effect on isolated smooth muscle. Lower concentration of extract caused contraction, while higher concentrations produced relaxation. The contractile phase was attenuated by atropine, while relaxant phase attenuated histamine induced contraction of guinea pig ileum. The extract also exhibited a dose-dependent inhibition of gastrointestinal motility. Acute toxicity test in mice established LD50 value (i.p.) of the extract to be 2000 mg/kg. Preliminary phytochemical screening of the extract gave positive test for flavonoids, tannins and saponins.en_US
dc.description.affiliationDepartment of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P. M. B. 21, Abuja, Nigeria. samsonamos@yahoo.co.uken_US
dc.identifier.citationAmos S, Binda L, Chindo B, Akah P, Abdurahman M, Danmallam HU, Wambebe C, Gamaniel K. Evaluation of methanolic extract of Ficus platyphylla on gastrointestinal activity. Indian Journal of Experimental Biology. 2001 Jan; 39(1): 63-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/57938
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDigestive System --drug effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastrointestinal Transit --drug effectsen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshLethal Dose 50en_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshRosales --chemistryen_US
dc.titleEvaluation of methanolic extract of Ficus platyphylla on gastrointestinal activity.en_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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