Homology Modelling and Docking Studies of Plant Derived Natural Compounds on Staphylococcus Aureus.

Simple item page
dc.contributor.authorAnitha, S
dc.date.accessioned2015-12-15T06:27:22Z
dc.date.available2015-12-15T06:27:22Z
dc.date.issued2014-10
dc.description.abstractStaphylococcus aureus avoid innate immune responses including phagocytosis is crucial for the organism to cause infection. This process involves several secreted and cell-surface-associated proteins. In this study I identified the action of plant compounds on Iron regulated surface protein using docking studies with homology modeled Surface protein. Through the modeled protein, the flexible Docking study was performed with plant derived compounds with theoretically predicted active sites. The results indicated that amino acid CYS-88, TYR-112 and LEU-113 present in Iron regulated surface protein are core important for binding activities and these residues are having strong hydrogen bond interactions with compounds. I have investigated the plant derived compounds like vannillic interactions and scoring parameters in GOLD, and the GOLD score results are interesting. Our results may be helpful for further investigations in both in vivo and in vitro conditions.en_US
dc.identifier.citationAnitha S. Homology Modelling and Docking Studies of Plant Derived Natural Compounds on Staphylococcus Aureus. International Journal of Applied Biology and Pharmaceutical Technology. 2014 Oct-Dec; 5(4): 56-65.en_US
dc.identifier.issn0976-4550
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/168173
dc.language.isoenen_US
dc.source.urihttps://www.ijabpt.com/Details.aspx?fid=1062en_US
dc.subjectIron regulated surface proteinen_US
dc.subjectModeller7v7en_US
dc.subjectMolecular dockingen_US
dc.subjectStaphylococcus aureusen_US
dc.titleHomology Modelling and Docking Studies of Plant Derived Natural Compounds on Staphylococcus Aureus.en_US
dc.typeArticleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
International Journal of Applied Biology and Pharmaceutical Technology