Antidiabetic activity of a polyherbal formulation (DRF/AY/5001).

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dc.contributor.authorMandlik, Rahul Ven_US
dc.contributor.authorDesai, Sandya Ken_US
dc.contributor.authorNaik, Suresh Ren_US
dc.contributor.authorSharma, Gauraven_US
dc.contributor.authorKohli, R Ken_US
dc.date.accessioned2009-05-28T10:46:08Z
dc.date.available2009-05-28T10:46:08Z
dc.date.issued2008-08-26en_US
dc.description.abstractThe herbal formulation, DRF/AY/5001, elicits hypoglycemic/antidiabetic effects in both normal and experimentally induced hyperglycemic (epinephrine and alloxan) rats. Further, herbal formulation treatment can significantly alter the pattern of glucose tolerance in normal and diabetic rats. It is possible that the herbal formulation may act through both, pancreatic and extra-pancreatic mechanism(s). The DRF/AY/5001 also elicited a significant antioxidant effect in alloxan diabetic rats as reflected by its ability to inhibit lipid peroxidation and to elevate the enzymatic antioxidants in pancreatic tissue. The histopathological studies during the long-term treatment have shown to ameliorate the alloxan induced histological damage of islets of Langerhans. The inhibitory effects on biochemical and histological parameters induced by herbal formulation at a dose of 600 mg/kg were almost comparable to that of standard drug, glibenclamide (4 mg/kg). The present study demonstrates that herbal formulation exhibits promisisng antidiabetic activity and helps to maintain good glycemic and metabolic control.en_US
dc.description.affiliationKM Kundnani College of Pharmacy, Colaba, Mumbai 400 005, India.en_US
dc.identifier.citationMandlik RV, Desai SK, Naik SR, Sharma G, Kohli RK. Antidiabetic activity of a polyherbal formulation (DRF/AY/5001). Indian Journal of Experimental Biology. 2008 Aug; 46(8): 599-606en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55771
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/4569/1/IJEB%2046%288%29%20599-606.pdfen_US
dc.titleAntidiabetic activity of a polyherbal formulation (DRF/AY/5001).en_US
dc.typeJournal Articleen_US
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