Demethylation of RARβ2 Gene Promoter by Withania somnifera in HeLa Cell Line.

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dc.contributor.authorJha, Abhimanyu Kumar
dc.contributor.authorNikbakht, Mohsen
dc.contributor.authorCapalash, Neena
dc.contributor.authorKaur, Jagdeep
dc.date.accessioned2015-10-08T11:50:56Z
dc.date.available2015-10-08T11:50:56Z
dc.date.issued2014-05
dc.description.abstractAn important molecular target for cancer therapy is the possible reactivation of tumor suppressor genes that have been silenced by promoter methylation. It was observed that the treatment of an adenocarcinoma cervical cancer cell line, HeLa with 20 μg/ml of the ethanolic extract of Withania somnifera for 6 days resulted in demethylation of promoter of RARβ2 gene. However, treatment with Ocimum sanctum and Azadirachta indica (20μg/ml) did not cause the reversal of hypermethylation after 6 days of treatment. This is the first report to show the reversal of hypermethylation of RARβ2 gene by Withania somnifera extract in a cervical cancer cell line.en_US
dc.identifier.citationJha Abhimanyu Kumar, Nikbakht Mohsen, Capalash Neena, Kaur Jagdeep. Demethylation of RARβ2 Gene Promoter by Withania somnifera in HeLa Cell Line. European Journal of Medicinal Plants. 2014 May; 4(5): 503-510.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/164119
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/3412en_US
dc.subjectMethylationen_US
dc.subjectadenocarcinomaen_US
dc.subjectRARβ2en_US
dc.subjectcervical cancer cell lineen_US
dc.titleDemethylation of RARβ2 Gene Promoter by Withania somnifera in HeLa Cell Line.en_US
dc.typeArticleen_US
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