Vasorelaxant effects of hydro-ethanol leaves extract of Adansonia digitata on different models of conductance and resistance vessels in rat

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dc.contributor.authorSene, Men_US
dc.contributor.authorDiouf, Ien_US
dc.contributor.authorBa, Aen_US
dc.contributor.authorNdiaye, Men_US
dc.contributor.authorBa, Fen_US
dc.contributor.authorToure, Men_US
dc.contributor.authorDiaw, NAen_US
dc.contributor.authorKane, MOen_US
dc.contributor.authorSarr, Men_US
dc.contributor.authorSchini-kerth, VB.en_US
dc.date.accessioned2025-05-14T09:32:53Z
dc.date.available2025-05-14T09:32:53Z
dc.date.issued2024-11
dc.description.abstractIntroduction: Adansonia digitata leaves are used in traditional medicine to treat high blood pressure in Senegal. The objective of this study was to evaluate the vasorelaxant effects of the hydroethanolic leaf extract of Adansonia digitata ADF (hydroethanolic leaf extract of Adansonia digitata) on rat mesenteric, carotid, femoral arteries, and thoracic aorta. Material and methods: Rat mesenteric, carotid, femoral arteries, and thoracic aorta rings were suspended in organ chambers for recording changes in isometric forces. They were then balanced for 45 minutes to a basal tension of 1 g and contracted with a KCl solution (80 mM) to verify the integrity of the arteries. After washing with Krebs solution and returning to a basal tension of 1 g, the rings were contracted again with phenylephrine (1 ?M) until the concentra- tion plateau was reached, then released by adding acetylcholine (ACh, 1 ?M). Vessels were considered to have func- tional endothelium when acetylcholine induced a relaxation greater than 90%. In some experiments, the endothelium was removed before contraction with phenylephrine and concentration-relaxation responses to ADF were measured. Results: ADF produced 91.43, 72.08, 68.89, and 71.32% relaxation, respectively, in superior mesenteric, carotid, femoral arteries, and thoracic aorta at 10 ?g/ml in endothelium-intact arteries pre-contracted with phenylephrine. Conclusion: Adansonia digitata induces vasodilation, which may explain its antihypertensive effect and its use in traditional African medicine.en_US
dc.identifier.affiliationsLaboratoire de Physiologie Pharmaceutique, Faculté de Médecine, de Pharmacie et d’Odontologie, Université Cheikh Anta Diop, BP 5005, Dakar, Sénégalen_US
dc.identifier.affiliationsUFR Santé, Université Assane Seck, Ziguinchor, Sénégalen_US
dc.identifier.affiliationsUFR Santé et développement durable, Université Alioune Diop, Bambey, Sénégalen_US
dc.identifier.affiliationsLaboratoire de Pharmacologie et Pharmacodynamie, Faculté de Médecine, de Pharmacie et d’Odontologie, Uni- versité Cheikh Anta Diop, BP 5005, Dakar, Sénégalen_US
dc.identifier.affiliationsUFR Santé, Université Gaston Berger, Saint-Louis, Sénégalen_US
dc.identifier.affiliationsLaboratoire de Physiologie et d’exploration fonctionnelle, Faculté de Médecine, de Pharmacie et d’Odontologie, Université Cheikh Anta Diop, BP 5005, Dakar, Sénégalen_US
dc.identifier.affiliationsLaboratoire de Physiologie Pharmaceutique, Faculté de Médecine, de Pharmacie et d’Odontologie, Université Cheikh Anta Diop, BP 5005, Dakar, Sénégalen_US
dc.identifier.affiliationsLaboratoire de Physiologie Pharmaceutique, Faculté de Médecine, de Pharmacie et d’Odontologie, Université Cheikh Anta Diop, BP 5005, Dakar, Sénégalen_US
dc.identifier.affiliationsLaboratoire de Physiologie Pharmaceutique, Faculté de Médecine, de Pharmacie et d’Odontologie, Université Cheikh Anta Diop, BP 5005, Dakar, Sénégalen_US
dc.identifier.affiliationsCentre de recherche en biomédecine de Strasbourg, Université de Strasbourg, Strasbourg, Franceen_US
dc.identifier.citationSene M, Diouf I, Ba A, Ndiaye M, Ba F, Toure M, Diaw NA, Kane MO, Sarr M, Schini-kerth VB.. Vasorelaxant effects of hydro-ethanol leaves extract of Adansonia digitata on different models of conductance and resistance vessels in rat . National Journal of Physiology, Pharmacy and Pharmacology. 2024 Nov; 14(11): 2372-2376en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247849
dc.languageenen_US
dc.publisher?Eldaghayes Publisheren_US
dc.relation.issuenumber11en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.5455/NJPPP.2024.v14.i11.6en_US
dc.subjectAdansonia digitataen_US
dc.subjectvasorelaxanten_US
dc.subjectrat arteriesen_US
dc.titleVasorelaxant effects of hydro-ethanol leaves extract of Adansonia digitata on different models of conductance and resistance vessels in raten_US
dc.typeJournal Articleen_US
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