Vasorelaxant effects of hydro-ethanol leaves extract of Adansonia digitata on different models of conductance and resistance vessels in rat
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Date
2024-11
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?Eldaghayes Publisher
Abstract
Introduction: Adansonia digitata leaves are used in traditional medicine to treat high blood pressure in Senegal. The objective of this study was to evaluate the vasorelaxant effects of the hydroethanolic leaf extract of Adansonia digitata ADF (hydroethanolic leaf extract of Adansonia digitata) on rat mesenteric, carotid, femoral arteries, and thoracic aorta. Material and methods: Rat mesenteric, carotid, femoral arteries, and thoracic aorta rings were suspended in organ chambers for recording changes in isometric forces. They were then balanced for 45 minutes to a basal tension of 1 g and contracted with a KCl solution (80 mM) to verify the integrity of the arteries. After washing with Krebs solution and returning to a basal tension of 1 g, the rings were contracted again with phenylephrine (1 ?M) until the concentra- tion plateau was reached, then released by adding acetylcholine (ACh, 1 ?M). Vessels were considered to have func- tional endothelium when acetylcholine induced a relaxation greater than 90%. In some experiments, the endothelium was removed before contraction with phenylephrine and concentration-relaxation responses to ADF were measured. Results: ADF produced 91.43, 72.08, 68.89, and 71.32% relaxation, respectively, in superior mesenteric, carotid, femoral arteries, and thoracic aorta at 10 ?g/ml in endothelium-intact arteries pre-contracted with phenylephrine. Conclusion: Adansonia digitata induces vasodilation, which may explain its antihypertensive effect and its use in traditional African medicine.
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Keywords
Adansonia digitata, vasorelaxant, rat arteries
Citation
Sene M, Diouf I, Ba A, Ndiaye M, Ba F, Toure M, Diaw NA, Kane MO, Sarr M, Schini-kerth VB.. Vasorelaxant effects of hydro-ethanol leaves extract of Adansonia digitata on different models of conductance and resistance vessels in rat . National Journal of Physiology, Pharmacy and Pharmacology. 2024 Nov; 14(11): 2372-2376