Identification of Phytocomponents and Acute Toxicity Evaluation of Corchorus olitorius Leaf Extract

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dc.contributor.authorOrieke, D.en_US
dc.contributor.authorOhaeri, O. C.en_US
dc.contributor.authorIjeh, I. I.en_US
dc.contributor.authorIjioma, S. N.en_US
dc.date.accessioned2020-01-02T06:13:51Z
dc.date.available2020-01-02T06:13:51Z
dc.date.issued2018-04
dc.description.abstractIn this study, the identification of secondary metabolites was carried out alongside acute toxicity evaluation on Corchorus olitorius leaf extract (COLE). Results of phytochemical analysis of the extract revealed the presence of flavonoids (4.00±0.035 mg/100 g), steroids (0.89±0.031 mg/100 g), terpenes (1.27±0.016 mg/100 g), phenolic compounds (2.05±0.514 mg/100 g), alkaloids (3.10±0.026 mg/100 g), saponins (4.00±0.054 mg/100 g), tannins (0.32±0.044 mg/100 g) and cardiac glycoside (1.61±0.068 mg/100 g) while GCMS analysis of the extract showed the presence of 46 compounds with 2-Dodecenal having the highest concentration. 3-Methyl-1-penten-4-yn-3-ol, 2,4-Decadienal and Ethanone were also found in higher amounts. No toxicity behaviour and mortality were observed during the acute toxicity study period, even at a dose of 5000 mg/kg body. From results obtained, we conclude that Corchorus olitorius leaf extract may be a potential source of antioxidant, anti-inflammatory, anticancer and cardiovascular system modulatory agent and may be safe for use as food and medicine.en_US
dc.identifier.affiliationsDepartment of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeriaen_US
dc.identifier.citationOrieke D., Ohaeri O. C., Ijeh I. I., Ijioma S. N.. Identification of Phytocomponents and Acute Toxicity Evaluation of Corchorus olitorius Leaf Extract. European Journal of Medicinal Plants. 2018 Apr; 23(1): 1-16en_US
dc.identifier.issn2231-0894
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/189393
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber1en_US
dc.relation.volume23en_US
dc.source.urihttps://doi.org/10.9734/EJMP/2018/38739en_US
dc.subjectCorchorus olitoriusen_US
dc.subjectGC-MSen_US
dc.subjectphytochemicalen_US
dc.subjecttoxicityen_US
dc.titleIdentification of Phytocomponents and Acute Toxicity Evaluation of Corchorus olitorius Leaf Extracten_US
dc.typeJournal Articleen_US
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