Effect of aspirin on blood-lipid interaction and lipid peroxidation phenomena in relation to partition coefficient and biological activity.

Simple item page
dc.contributor.authorSaha, Aen_US
dc.contributor.authorDe, A Uen_US
dc.contributor.authorSengupta, Cen_US
dc.date.accessioned2009-05-28T14:50:31Z
dc.date.available2009-05-28T14:50:31Z
dc.date.issued2000-09-04en_US
dc.description.abstractConsidering the lipophilicity of aspirin (log P = -1.15), a significant contributor to its action mechanism, interaction of the drug with the whole lipids of goat blood have been investigated using phospholipid binding and lipid peroxidation phenomena as the parameters under investigation. The lipid content change along with the peroxidation induced by aspirin and its suppression with ascorbic acid had been quantitatively measured. Significant loss in phospholipid was observed after incubation of whole blood with aspirin in varying periods of time. This may be ascribed to binding affinity of aspirin with lipid constituents in blood, which may have potential role in its therapeutic effect. Lipid peroxidation induction potential of aspirin caused significant extent of peroxidation. Ascorbic acid, an antioxidant could significantly reduce aspirin induced lipid peroxidation.en_US
dc.description.affiliationDepartment of Chemical Technology, University Calcutta, 92, A P C Road, Calcutta 700 009, India.en_US
dc.identifier.citationSaha A, De AU, Sengupta C. Effect of aspirin on blood-lipid interaction and lipid peroxidation phenomena in relation to partition coefficient and biological activity. Indian Journal of Experimental Biology. 2000 Sep; 38(9): 912-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61226
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --pharmacologyen_US
dc.subject.meshAspirin --pharmacologyen_US
dc.subject.meshFatty Acids --blooden_US
dc.subject.meshGoatsen_US
dc.subject.meshLipid Peroxidation --drug effectsen_US
dc.subject.meshLipids --blooden_US
dc.subject.meshPhosphorus --analysisen_US
dc.titleEffect of aspirin on blood-lipid interaction and lipid peroxidation phenomena in relation to partition coefficient and biological activity.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology