Spindle damaging effect of salbutamol sulphate on bone marrow cells of mice.

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dc.contributor.authorSujatha, T Ven_US
dc.contributor.authorHegde, M Jen_US
dc.date.accessioned2009-05-28T14:26:39Z
dc.date.available2009-05-28T14:26:39Z
dc.date.issued1999-02-21en_US
dc.description.abstractIn vivo assessment and identification of aneuploidy are important phases of genotoxicity evaluation. Considerable effort has been devoted to assess the utility of the existing bioassays and to develop simpler techniques for identifying environmental aneugens. Salbutamol sulphate--an antiasthmatic drug was tested for its spindle damaging effects in bone marrow cells of mice using an in vivo technique, for the evaluation of mitotic index, C-mitotic effects, anaphase reduction and hyperdiploidy. Doses of 0.12, 0.24, 1.2, 2.4, mg/kg body weight were dissolved in bidistilled water and administered intraperitoneally to the mice. Colchicine was taken as positive control for its known aneuploidy-inducing effects. The drug showed positive C-mitotic effects accompanied with increases of mitotic index and decreased frequencies of anaphase in higher doses. Significant levels of hypodiploidy also noted at higher doses. The preliminary results indicated that Salbutamol is capable of inducing C-mitotic effects in mouse bone marrow cells, which is suggestive of possible induction of aneuploidy.en_US
dc.description.affiliationDepartment of Post Graduate Studies and Research in Biosciences, Mangalore University, Mangalagangotri, India.en_US
dc.identifier.citationSujatha TV, Hegde MJ. Spindle damaging effect of salbutamol sulphate on bone marrow cells of mice. Indian Journal of Experimental Biology. 1999 Feb; 37(2): 161-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60716
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAlbuterol --toxicityen_US
dc.subject.meshAneuploidyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Asthmatic Agents --toxicityen_US
dc.subject.meshBone Marrow Cells --drug effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMitotic Spindle Apparatus --drug effectsen_US
dc.titleSpindle damaging effect of salbutamol sulphate on bone marrow cells of mice.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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