Comparison of Effect of Enalapril and Losartan Monotherapy on Quality of Life and Safety of Stage 1 Hypertensive Patients.
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Date
2016-04
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Abstract
An open label randomized controlled study was conducted to compare the quality of life (QoL) and safety
of newly diagnosed stage 1 hypertensive patients randomized into two groups of 30 receiving either enalapril
5 mg or losartan 50 mg per-oral once daily for three months. QoL was assessed at the baseline and at the
end of study using SF-36v2 health care questionnaire. Adverse drug reactions (ADRs) were monitored.
Investigations at baseline were compared with those after intervention.
Pre & post-intervention QoL transformed scores within each group and change in the same between two
groups were analyzed using paired and unpaired t-test respectively.
Transformed scores of role limitation due to energy/fatigue, emotional well being and general health domains
improved significantly in both treatment groups. Scores of bodily pain improved significantly (p=0.0008) in
losartan group only.
Results were not significantly different between two groups (except for bodily pain). No serious ADR was
reported.
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Citation
Vikas Maharshi*, Harmeet Singh Rehan, Lalit Kumar Gupta and Madhur Yadav. Comparison of Effect of Enalapril and Losartan Monotherapy on Quality of Life and Safety of Stage 1 Hypertensive Patients. Indian Journal of Physiology and Pharmacology. 2016 Apr-Jun; 60(2): 174-181.