Analysis of spontaneously reported cutaneous adverse drug reactions in a tertiary care teaching hospital in South India

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dc.contributor.authorKonda, Vijaya Chandra Reddyen_US
dc.contributor.authorPilla, Sree Surya Durga Devien_US
dc.contributor.authorSurekha, A.en_US
dc.contributor.authorSubash, K. R.en_US
dc.contributor.authorRao, K. Umamaheswaraen_US
dc.date.accessioned2020-04-23T07:53:26Z
dc.date.available2020-04-23T07:53:26Z
dc.date.issued2019-01
dc.description.abstractBackground: Skin is the most common organ involved in adverse reactions due to drugs. With newer drugs released into market every year, there is changing pattern of the reported cutaneous adverse drug reactions (ADRs). In order to ensure safer use of medicines in patients, there is need for continuous monitoring of ADRs. This is a retrospective study to analyse spontaneously reported cutaneous ADRs.Methods: All the cutaneous ADRs reported between January 2017 and September 2018 were analysed for clinical patterns, suspected medications, causality, severity and preventability.Results: Of the 1035 reports received during the study period, 232 (22.41%) included cutaneous reactions. 113 (48.7%) were male and 119 (51.29%) were female. Maculopapular rash 70 (30.17%), pruritus 31 (13.36%), palmar plantar erythrodysesthesia 30 (12.93%), acne 19 (8.19%), urticaria 16 (6.89%) and fixed drug eruptions (FDE) 13 (5.6%) were the common clinical patterns. Antimicrobial agents followed by anticancer drugs, nonsteroidal anti-inflammatory drugs (NSAIDs), hormones and related drugs, and antiepileptic drugs were the common suspected group of drugs. Causality assessment as done by WHO-UMC scale showed that 3 (1.29%) were certainly related, 174 (75%) were probably related and 55 (23.7%) were possibly related to the suspected medication.Conclusions: Cutaneous ADRs are most frequently reported ADRs in the present study. With newer drugs released into market, there is a need for continuous monitoring of use of drugs to promote safer use of medicines in patients.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Sri Venkateswara Institute of Medical Sciences, Sri Padmavathi Medical College for Women, Tirupati, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsADR Monitoring Centre, Sri Venkateswara Institute of Medical Sciences, Sri Padmavathi Medical College for Women, Tirupati, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Dermatology, Sri Venkateswara Institute of Medical Sciences, Sri Padmavathi Medical College for Women, Tirupati, Andhra Pradesh, Indiaen_US
dc.identifier.citationKonda Vijaya Chandra Reddy, Pilla Sree Surya Durga Devi, Surekha A., Subash K. R., Rao K. Umamaheswara. Analysis of spontaneously reported cutaneous adverse drug reactions in a tertiary care teaching hospital in South India. International Journal of Basic & Clinical Pharmacology. 2019 Jan; 8(1): 27-33en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199996
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20185085en_US
dc.subjectAdverse drug reaction monitoring centreen_US
dc.subjectCutaneous adverse drug reactionsen_US
dc.subjectCausalityen_US
dc.subjectPharmacovigilanceen_US
dc.titleAnalysis of spontaneously reported cutaneous adverse drug reactions in a tertiary care teaching hospital in South Indiaen_US
dc.typeJournal Articleen_US
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