Assessment of minimum inhibitory concentration to vancomycin, tigecycline, linezolid, daptomycin, ceftaroline and mupirocin against methicillin resistant Staphylococcus aureus clinical isolates by antibiotic gradient strips

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dc.contributor.authorN., A.en_US
dc.contributor.authorP., R. D.en_US
dc.contributor.authorN., S.en_US
dc.contributor.authorPremanandan, F.en_US
dc.contributor.authorK. B., A.en_US
dc.contributor.authorSathar, S.en_US
dc.contributor.authorKumar K. S., H.en_US
dc.date.accessioned2024-09-24T06:13:47Z
dc.date.available2024-09-24T06:13:47Z
dc.date.issued2024-04
dc.description.abstractBackground: Staphylococcus aureus infections are one of the most common and serious hospital-acquired infections seen in developing countries. Methicillin resistant Staphylococcus aureus (MRSA) is an important human pathogen and normally colonized in body parts including skin, nose, perineum and throat. MRSA is resistant not only to all ?-lactam groups but also other antibiotics including aminoglycosides, tetracycline and macrolides. In the present study the efficacy of agents used in the management of MRSA infections was determined by antibiotic gradient testing. Methods: A total of 60 clinical isolates of MRSA strains were collected from various diagnostic labs in central Kerala. Clinical isolates were reconfirmed as MRSA by gram staining, yellow-coloured colonies on mannitol salt Agar (MSA). Antibiotic susceptibility testing was done by disc diffusion method as recommended by CLSI guidelines. S. aureus isolates resistant to cefoxitin (30 µg) was identified as MRSA. Antibiotic gradient testing was performed to determine the MIC of vancomycin, tigecycline, linezolid, daptomycin, ceftaroline and mupirocin against MRSA isolates. Results: All the 60 MRSA isolates tested were sensitive to vancomycin, tigecycline, linezolid, daptomycin, ceftaroline and mupirocin (100%) and none of the MRSA isolates show resistance. Conclusions: Results of present study indicates that these agents may be used alongside vancomycin in management of infection caused by MRSA.en_US
dc.identifier.affiliationsDepartment of Medical Microbiology, School of Medical Education, Centre for Professional and Advanced Studies, Kottayam, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, School of Medical Education, Centre for Professional and Advanced Studies, Kottayam, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, School of Medical Education, Centre for Professional and Advanced Studies, Kottayam, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, School of Medical Education, Centre for Professional and Advanced Studies, Kottayam, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, School of Medical Education, Centre for Professional and Advanced Studies, Kottayam, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, School of Medical Education, Centre for Professional and Advanced Studies, Kottayam, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, School of Medical Education, Centre for Professional and Advanced Studies, Kottayam, Kerala, Indiaen_US
dc.identifier.citationN. A., P. R. D., N. S., Premanandan F., K. B. A., Sathar S., Kumar K. S. H.. Assessment of minimum inhibitory concentration to vancomycin, tigecycline, linezolid, daptomycin, ceftaroline and mupirocin against methicillin resistant Staphylococcus aureus clinical isolates by antibiotic gradient strips. International Journal of Basic & Clinical Pharmacology. 2024 Mar; 13(2): 245-249en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226726
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume13en_US
dc.source.urihttps://doi.org/10.18203/2319-2003.ijbcp20240380en_US
dc.subjectMRSAen_US
dc.subjectMinimum inhibitory concentrationen_US
dc.subjectMultidrug resistanceen_US
dc.subjectAnti-MRSA drugsen_US
dc.subjectDecolonizationen_US
dc.titleAssessment of minimum inhibitory concentration to vancomycin, tigecycline, linezolid, daptomycin, ceftaroline and mupirocin against methicillin resistant Staphylococcus aureus clinical isolates by antibiotic gradient stripsen_US
dc.typeJournal Articleen_US
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