Pharmacogenomics and Precision Medicine in Psychiatry: A Comprehensive Review

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dc.contributor.authorRao, T. R.en_US
dc.contributor.authorSravya, G.en_US
dc.contributor.authorAkshaya, D.en_US
dc.contributor.authorKaushik, T.en_US
dc.date.accessioned2024-09-24T08:28:04Z
dc.date.available2024-09-24T08:28:04Z
dc.date.issued2024-06
dc.description.abstractThree primary phenotypes in psychiatry have been the focus of pharmacogenetic studies: the development of side effects related to psychotropic drug treatment, the clinical effectiveness of antipsychotic drugs, and the efficacy of antidepressant medications. Pharmacokinetic or pharmacodynamic effects are the two categories into which pharmacogenetic studies of antidepressants can be divided. Genetic variations that impact antidepressant metabolism can alter pharmacokinetic parameters like plasma drug concentration and half-life. Pharmacodynamics may be changed by polymorphisms that impact the expression or operation of receptors and signal transduction molecules in the brain. Changes in pharmacokinetics and pharmacodynamics can impact antidepressant effectiveness and adverse effects. Using molecular genetic techniques offers a new way to analyze the variability in the response to psychotropic drugs. Traditionally known as "pharmacogenetics," this area of study offers several unique benefits for identifying informative correlates of psychotropic drug response. This shift from a one-size-fits-all approach to a targeted, patient-specific strategy holds the potential to revolutionize psychiatric care, providing more effective and efficient treatments. Additionally, precision medicine in psychiatry contributes to reducing trial-and-error prescribing, ultimately improving patient outcomes and the overall quality of mental health care. Student, CMR C.en_US
dc.identifier.affiliationsDepartment of Pharm D, CMR College of Pharmacy, Hyderabad, Indiaen_US
dc.identifier.affiliationsDepartment of Pharm D, CMR College of Pharmacy, Hyderabad, Indiaen_US
dc.identifier.affiliationsDepartment of Pharm D, CMR College of Pharmacy, Hyderabad, Indiaen_US
dc.identifier.affiliationsDepartment of Pharm D, CMR College of Pharmacy, Hyderabad, Indiaen_US
dc.identifier.citationRao T. R., Sravya G., Akshaya D., Kaushik T. . Pharmacogenomics and Precision Medicine in Psychiatry: A Comprehensive Review . International Journal of Pharmaceutical Research and Allied Sciences . 2024 Apr; 13(2): 97-103en_US
dc.identifier.issn2277-3657
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/231422
dc.languageenen_US
dc.publisherMeral Publisheren_US
dc.relation.issuenumber2en_US
dc.relation.volume13en_US
dc.source.urihttps://doi.org/10.51847/cPavouwbc4en_US
dc.subjectPharmacogeneticsen_US
dc.subjectPharmacokineticsen_US
dc.subjectPharmacodynamicsen_US
dc.subjectAntidepressantsen_US
dc.subjectAntipsychoticsen_US
dc.titlePharmacogenomics and Precision Medicine in Psychiatry: A Comprehensive Reviewen_US
dc.typeJournal Articleen_US
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