Measles virus phosphoprotein inhibits apoptosis and enhances clonogenic and migratory properties in HeLa cells

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dc.contributor.authorBhattacharjee, Sankhajiten_US
dc.contributor.authorJaiswal, Rishi Kumaren_US
dc.contributor.authorYadava, Pramod Kumaren_US
dc.date.accessioned2020-11-18T10:14:30Z
dc.date.available2020-11-18T10:14:30Z
dc.date.issued2019-03
dc.description.abstractMeasles virus is the causative agent of measles, a major cause of child mortality in developing countries. Two majorproteins, coded by the viral genome, are nucleocapsid protein (N) and phosphoprotein (P). The N protein protects the viralgenomic RNA and forms ribonucleoprotein complex (RNP) together with P protein. MeV-P protein recruits the largeprotein (L), i.e. viral RNA-depended RNA polymerase (RdRp), to ensure viral replication in host cell. Apoptogenicproperties of N protein of Edmonston vaccine strain have been established in our lab previously. We investigated the role ofMeV-P protein of Edmonston vaccine strain as modulator of apoptosis in cervical cancer cell line (HeLa) and found thatMeV-P protein is anti-apoptotic and enhances cell proliferation. Measles virus is considered to be innately oncotropic virus.However, the anti-apoptotic property of MeV-P protein raises important concerns while adopting this virus as an anti-cancertherapeutic tool.en_US
dc.identifier.affiliationsApplied Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, Indiaen_US
dc.identifier.citationBhattacharjee Sankhajit, Jaiswal Rishi Kumar, Yadava Pramod Kumar. Measles virus phosphoprotein inhibits apoptosis and enhances clonogenic and migratory properties in HeLa cells. Journal of Biosciences. 2019 Mar; 44(1): 1-9en_US
dc.identifier.issn0250-5991
dc.identifier.issn0973-7138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214435
dc.languageenen_US
dc.publisherIndian Academy of Sciencesen_US
dc.relation.issuenumber1en_US
dc.relation.volume44en_US
dc.source.urihttps://dx.doi.org//10.1007/s12038-018-9834-6en_US
dc.subjectAnti-apoptosisen_US
dc.subjectcell migrationen_US
dc.subjectclonogenicity, HeLa cellsen_US
dc.subjectmeasles virusen_US
dc.subjectphosphoproteinen_US
dc.subjectVimentinen_US
dc.titleMeasles virus phosphoprotein inhibits apoptosis and enhances clonogenic and migratory properties in HeLa cellsen_US
dc.typeJournal Articleen_US
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