Measles virus phosphoprotein inhibits apoptosis and enhances clonogenic and migratory properties in HeLa cells
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Date
2019-03
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Sciences
Abstract
Measles virus is the causative agent of measles, a major cause of child mortality in developing countries. Two majorproteins, coded by the viral genome, are nucleocapsid protein (N) and phosphoprotein (P). The N protein protects the viralgenomic RNA and forms ribonucleoprotein complex (RNP) together with P protein. MeV-P protein recruits the largeprotein (L), i.e. viral RNA-depended RNA polymerase (RdRp), to ensure viral replication in host cell. Apoptogenicproperties of N protein of Edmonston vaccine strain have been established in our lab previously. We investigated the role ofMeV-P protein of Edmonston vaccine strain as modulator of apoptosis in cervical cancer cell line (HeLa) and found thatMeV-P protein is anti-apoptotic and enhances cell proliferation. Measles virus is considered to be innately oncotropic virus.However, the anti-apoptotic property of MeV-P protein raises important concerns while adopting this virus as an anti-cancertherapeutic tool.
Description
Keywords
Anti-apoptosis, cell migration, clonogenicity, HeLa cells, measles virus, phosphoprotein, Vimentin
Citation
Bhattacharjee Sankhajit, Jaiswal Rishi Kumar, Yadava Pramod Kumar. Measles virus phosphoprotein inhibits apoptosis and enhances clonogenic and migratory properties in HeLa cells. Journal of Biosciences. 2019 Mar; 44(1): 1-9