Correlation between degree of protection and humoral antibody response in hamsters immunized with somatic and excretory secretory antigens of Ancylostoma ceylanicum.

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dc.contributor.authorKhan, A Men_US
dc.contributor.authorGupta, Sen_US
dc.contributor.authorKatiyar, J Cen_US
dc.contributor.authorSrivastava, V Ken_US
dc.date.accessioned2009-05-28T13:48:06Z
dc.date.available2009-05-28T13:48:06Z
dc.date.issued1996-10-01en_US
dc.description.abstractCorrelation between the degree of protection and induced serum antibody response in hamsters immunized with somatic and excretory-secretory (ES) antigens of adult. A. ceylanicum was investigated. Hamsters were immunized with non purified and Sephadex G-200 fractions (F1, F2 and F3) of somatic and ES antigens. The degree of protection was assessed in terms of percent worm reduction compared to controls against challenge infection. Induced humoral antibody response was determined by ELISA. Both somatic and ES antigens had shown moderate to significant protection but the latter was found more immunogenic as highest level of protection (67.02%) was achieved by these antigens. Humoral antibody was found highly elevated in animals immunized with protective doses of somatic and ES antigens. The maximum serum antibody titer i.e. 1:3200 was noticed in animals immunized with high protective dose (64.59% protection) of fraction F1 of ES antigens. Antibody titer correspond to the degree of protection and a positive correlation between induced humoral antibodies and protection level was established.en_US
dc.description.affiliationParasitology Division, Central Drug Research Institute, Lucknow, India.en_US
dc.identifier.citationKhan AM, Gupta S, Katiyar JC, Srivastava VK. Correlation between degree of protection and humoral antibody response in hamsters immunized with somatic and excretory secretory antigens of Ancylostoma ceylanicum. Indian Journal of Experimental Biology. 1996 Oct; 34(10): 1015-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59882
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAncylostoma --immunologyen_US
dc.subject.meshAncylostomiasis --immunologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Helminth --biosynthesisen_US
dc.subject.meshAntigens, Helminth --administration & dosageen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunizationen_US
dc.subject.meshMaleen_US
dc.subject.meshMesocricetusen_US
dc.titleCorrelation between degree of protection and humoral antibody response in hamsters immunized with somatic and excretory secretory antigens of Ancylostoma ceylanicum.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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