Therapeutic effects of Erythrina variegata on primary dysmenorrhea and endometriosis: An in silico analysis

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dc.contributor.authorM, Snehaen_US
dc.contributor.authorR, Preyengaen_US
dc.contributor.authorB, Kayalvizhien_US
dc.date.accessioned2025-06-18T11:43:10Z
dc.date.available2025-06-18T11:43:10Z
dc.date.issued2025-05
dc.description.abstractPrimary dysmenorrhea (PD) is painful menstrual cramps, while endometriosis (EM) is a condition where tissue like the uterine lining grows outside the uterus, causing pain and infertility. EM and PD commonly associated in nociceptive pathways and inflammatory responses. In this study, phytochemicals such as erycrystagallin, erystagallin A, eryvarine A, 4-hydroxy-6, 3, 5 triprenyl isoflavonone, eryvarinol A, orientanol B from E. variegata have been evaluated for its potential to regulate TNF, COX-1, COX-2, PGF 2? involved in the inflammatory pathway resulting in hypersecretion of prostaglandins thereby causing excessive constriction of uterine muscle, nerve sensitization which leads to unbearable pain in PD. Similarly, employing network analysis in STRING and Cytoscape along with molecular docking in PyRx, the phytochemicals were investigated for their potential against PSR, ESR1, SF1, CYP19A1, GATA6, and MMP2, which creates an epigenetic abnormality converting stromal cells to endometriotic lesions and triggering inflammation through excessive production of estrogen. Using Cytoscape, the ligands with strong ADMET characteristics were found, and their interactions with the targets were verified. Molecular docking was performed to visualise the target-ligand complexes with the lowest binding affinities between -9 and -9.9. Hydrophobic and electrostatic interactions confirmed theligands' influence on the targets. E. variegata ceases primary dysmenorrhea from developing into endometriosis. Additionally, it minimises estrogen and progesterone imbalances associated with EM & PD.en_US
dc.identifier.affiliationsEvolute Bioscience, Woraiyur, Tiruchirappalli 620003, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsResearch Scholar, Department of Biotechnology, Bishop Heber College (Autonomous), Affiliated to Bharathidasan University, Tiruchirappalli 620017, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsEvolute Bioscience, Woraiyur, Tiruchirappalli 620003, Tamil Nadu, Indiaen_US
dc.identifier.citationM Sneha, R Preyenga, B Kayalvizhi . Therapeutic effects of Erythrina variegata on primary dysmenorrhea and endometriosis: An in silico analysis . Indian Journal of Experimental Biology. 2025 May; 63(5): 425-434en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249442
dc.languageenen_US
dc.publisherThe CSIR-National Institute of Science Communication and Policy Research (CSIR-NIScPR) (formerly known as NISCAIR).en_US
dc.relation.issuenumber5en_US
dc.relation.volume63en_US
dc.source.urihttps://doi.org/10.56042/ijeb.v63i05.14540en_US
dc.subjectMolecular dockingen_US
dc.subjectCyclooxygenasesen_US
dc.subjectProstaglandinsen_US
dc.subjectEstrogen receptorsen_US
dc.subjectAromataseen_US
dc.subject4-hydroxy-6,3,5 triprenyl isoflavononeen_US
dc.titleTherapeutic effects of Erythrina variegata on primary dysmenorrhea and endometriosis: An in silico analysisen_US
dc.typeJournal Articleen_US
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