Short term treatment of tamoxifen and estradiol on estradiol and progesterone receptors in rabbit uterus.

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dc.contributor.authorBhargava, Sen_US
dc.contributor.authorMurugesan, Ken_US
dc.contributor.authorVij, Uen_US
dc.contributor.authorBharti, Aen_US
dc.contributor.authorFarooq, Aen_US
dc.date.accessioned2009-05-28T15:41:44Z
dc.date.available2009-05-28T15:41:44Z
dc.date.issued1993-08-01en_US
dc.description.abstractEffects of tamoxifen (Tam) on cytosolic estradiol (E2) receptors (ERc), progesterone (P4) receptors (PRc), nuclear estradiol (ERn) and progesterone receptors (PRn) were studied in adult normal rabbit uterine tissue. The ratio of cytosol: nuclear estradiol receptors (ER) was greater in rabbits treated with Tam than E2 or control uterine tissues. Rabbit uterine progesterone receptors (PR) in E2 treated animal were greater than Tam-treated animals. Tam caused nuclear accumulation of estradiol receptor, and simultaneous administration of E2 + Tam 500, estradiol could not revert Tam mediated accumulation of ER. The results suggest that Tam has an essentially antagonist action in the rabbit uterine tissue.en_US
dc.description.affiliationDepartment of Reproductive Biology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationBhargava S, Murugesan K, Vij U, Bharti A, Farooq A. Short term treatment of tamoxifen and estradiol on estradiol and progesterone receptors in rabbit uterus. Indian Journal of Experimental Biology. 1993 Aug; 31(8): 673-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62298
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEstradiol --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshRabbitsen_US
dc.subject.meshReceptors, Estradiol --drug effectsen_US
dc.subject.meshReceptors, Progesterone --drug effectsen_US
dc.subject.meshTamoxifen --pharmacologyen_US
dc.subject.meshUterus --drug effectsen_US
dc.titleShort term treatment of tamoxifen and estradiol on estradiol and progesterone receptors in rabbit uterus.en_US
dc.typeJournal Articleen_US
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