Effect of dexmeditomidine on postoperative junctional ectopic tachycardia after complete surgical repair of tetralogy of Fallot: A prospective randomized controlled study.

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dc.contributor.authorKadam, Shankar V
dc.contributor.authorRao, Suresh G
dc.contributor.authorTailor, Kamlesh B
dc.contributor.authorKulkarni, Snehal
dc.contributor.authorMohanty, Smrutiranjan R
dc.contributor.authorJoshi, Preetha V
dc.contributor.authorRao, Suresh Gb
dc.date.accessioned2015-08-22T08:23:00Z
dc.date.available2015-08-22T08:23:00Z
dc.date.issued2015-07
dc.description.abstractIntroduction: Incidence of junctional ectopic tachycardia (JET) after repair of tetralogy of Fallot (TOF) is 5.6–14%. Dexmeditomidine is a α-2 adrenoceptor agonist modulates the release of catecholamine, resulting in bradycardia and hypotension. These effects are being explored as a therapeutic option for the prevention of perioperative tachyarrhythmia. We undertook this study to examine possible preventive effects of dexmedetomidine on postoperative JET and its impact on the duration of ventilation time and length of Intensive Care Unit stay. Methods: After obtaining approval from the hospitals ethics committee and written informed consent from parents, this quasi-randomized trial was initiated. Of 94 patients, 47 patients received dexmedetomidine (dexmedetomidine group) and 47 patients did not receive the drug (control group). Results: Dexmedetomidine group had more number of complex variants like TOF with an absent pulmonary valve or pulmonary atresia (P = 0.041). Hematocrit on cardiopulmonary bypass (CPB), heart rate while coming off from CPB and inotrope score was significantly low in the dexmedetomidine group compared to control group. The incidence of JET was significantly low in dexmedetomidine group (P = 0.040) compared to control group. Conclusions: Dexmedetomidine may have a potential benefit of preventing perioperative JET.en_US
dc.identifier.citationKadam Shankar V, Tailor Kamlesh B, Kulkarni Snehal, Mohanty Smrutiranjan R, Joshi Preetha V, Rao Suresh G. Effect of dexmeditomidine on postoperative junctional ectopic tachycardia after complete surgical repair of tetralogy of Fallot: A prospective randomized controlled study. Annals of Cardiac Anaesthesia. 2015 Jul; 18(3): 323-328.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/162331
dc.language.isoenen_US
dc.source.urihttps://www.annals.in/article.asp?issn=0971-9784;year=2015;volume=18;issue=3;spage=323;epage=328;aulast=Kadamen_US
dc.subjectDexmedetomidineen_US
dc.subjectJunctional ectopic tachycardiaen_US
dc.subjectTetralogy of Falloten_US
dc.subject.meshChild, Preschool
dc.subject.meshDexmedetomidine --administration & dosage
dc.subject.meshDexmedetomidine --therapeutic use
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshTachycardia, Ectopic Junctional --drug therapy
dc.subject.meshTachycardia, Ectopic Junctional --prevention & control
dc.subject.meshTachycardia, Ectopic Junctional --surgery
dc.subject.meshTetralogy of Fallot --epidemiology
dc.subject.meshTetralogy of Fallot --surgery
dc.titleEffect of dexmeditomidine on postoperative junctional ectopic tachycardia after complete surgical repair of tetralogy of Fallot: A prospective randomized controlled study.en_US
dc.typeArticleen_US
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